The main clinical causes of thumb joint pain include: sprain of thumb joint, trauma leading to soft tissue injury, and even fracture leading to thumb joint pain. Excessive activity can cause arthritis, tenosynovitis and other inflammation, which can lead to joint pain in the hands and thumbs. Patients with rheumatoid arthritis, rheumatism, gout, systemic lupus erythematosus and other diseases will cause joint pain in the hands and thumbs. Long term contact with cold water is likely to cause osteoarthritis of the interphalangeal joint, as well as swelling and pain of the interphalangeal joint. The patient has cervical spondylosis. When the cervical vertebra compresses the nerve root, it will cause pain in the thumb joint. Carpal tunnel syndrome can also cause pain in the thumb joint of the hand.