The 44 year old menopause is relatively early. Because with the improvement of women's quality of life, premature menopause is prone to osteoporosis, or senile dementia after old age, which is prone to cardiovascular diseases and other complications. Therefore, in case of premature menopause, a healthy physical examination should be carried out, and color Doppler ultrasound should be performed to understand the conditions of uterine appendages and endometrium; It is necessary to check the liver and kidney functions, blood sugar, blood lipids, and breast color ultrasound, hormone levels. If there is no abnormality in the examination and no contraindication to taking medicine, hormone drug replacement treatment can be given to restore menstruation. Because during menstruation, it can protect endometrium, reduce complications, alleviate climacteric syndrome, and treat vaginal atrophy, urogenital diaphragm infection and other diseases.