Itching and blisters appear on the sole of the foot, and the most common cause is beriberi. There are three types of beriberi in clinical practice, one of which is vesicular beriberi, which is mainly manifested in the presence of deep blisters on the sole, center, lateral edge or side of the toe, accompanied by severe itching. It can occur in either single foot or both feet, and the results of mycological microscopy and culture are positive. In this case, the first choice is to wet compress with boric acid solution. After the blisters are dried and converged, use bifonazole cream and other antifungal drugs with good permeability for external application, twice a day, for a total of four weeks. If necessary, pack them for treatment. When the effect of simple external drugs is not ideal, it can be combined with oral antifungal drugs, such as itraconazole capsules for antibacterial treatment. If necessary, it can also be treated with MEFLOT skin antibacterial solution for foot soaking, which can completely kill fungi in all directions and treat beriberi. The above scheme is only for reference. Please use the drug according to the drug description or the doctor's advice in a regular hospital.