Urticaria is itchy at night, which can be treated with antihistamines. Common drugs include chlorphenamine, loratadine, ebastine, cetirizine, etc., which can exert effects in a relatively short time to control itching. Locally, calamine lotion can also be used for external rubbing or local cold compress to reduce the itching symptoms by reducing body surface temperature and contracting blood vessels. Urticaria is a common allergic skin disease. The main clinical manifestation is erythema, wheals, itching and other symptoms on the skin. If the onset of urticaria and itching occur at night, drug treatment can be used. If necessary, intramuscular injection of chlorpheniramine and diphenhydramine can be used to control. In addition, we should actively search for and remove allergens, eat a light diet, and do not eat fish, shrimp, seafood, spicy and stimulating food.