Cold medicine can be taken with cephalosporin. Cold medicine is mainly used to treat nasal congestion, runny nose, sore throat and fever caused by upper respiratory tract infection. Cephalosporins are mainly antibiotics and beta lactams, which have bactericidal and anti-inflammatory effects on gram-positive cocci and gram-negative bacilli. Cold medicine and cephalosporin can play a synergistic role when taken orally together. However, you should not drink alcohol when eating cephalosporins. Drinking alcohol will lead to disulfiram reaction. In mild cases, fever, rash and dyspnea may occur, and in severe cases, life may be endangered. Drink more water, eat more fresh fruits and vegetables, avoid spicy and stimulating food, keep warm and prevent coldness.