Strengthen heart, diuresis, expand coronary artery, excite respiratory center and respiratory muscle. Aminophylline has the function of relaxing bronchial smooth muscle, strengthening heart, diuresis, expanding coronary artery, exciting respiratory center and respiratory muscle. The therapeutic window of aminophylline is relatively narrow, and there are large individual differences in aminophylline metabolism, which can cause arrhythmia, blood pressure decline and even death. If possible, the blood concentration should be monitored, and the concentration and dropping rate of aminophylline should be adjusted in time. The effective and safe plasma concentration of aminophylline ranges from 6 to 15 mg/L. There are many factors affecting theophylline metabolism, such as febrile diseases, pregnancy, and anti tuberculosis treatment, which can reduce the blood concentration of theophylline. Liver diseases, congestive heart failure, and the combination of quinolones, macrolides and other drugs can affect theophylline metabolism, slow its excretion, and increase the toxicity of aminophylline. The clinical indications of aminophylline include relieving the wheezing symptoms of asthma, asthmatic bronchitis, emphysema and other diseases. It can be used for cardiogenic asthma, and can also be used for patients with bronchospasm accompanied by chronic bronchitis and emphysema. His contraindications include peptic ulcer allergic to aminophylline or intolerable, uncontrolled convulsive diseases, including incurable potential epilepsy, acute myocardial infarction, and patients with decreased blood pressure.
