Clinical depression is a common psychosocial disease, which belongs to emotional disorder, and is a general term for a class of diseases mainly characterized by low mood or mood. Clinically, there may be cognitive and behavioral changes of different degrees. Some patients, especially those with major depression, may be accompanied by psychotic symptoms, such as hallucinations and delusions. Some patients have thoughts or behaviors of suicide, self injury, self mutilation, or even death when they are serious. Depression is a chronic recurrent disease. In the course of treatment, if treated systematically and normatively, most of them can be relieved, and some patients may have some symptoms left or become chronic, which may cause damage to social and occupational functions to varying degrees. In clinical practice, patients with depression often do not have clinical manifestations of mania and hypomania. Once they do, they need to be diagnosed as bipolar affective disorder clinically. In clinical practice, the treatment of depression mainly includes systematic antidepressant drug treatment, psychotherapy and physical therapy.