The causes of edema in diabetic patients mainly include the following aspects: First, diabetic nephropathy will produce a large amount of proteinuria, leading to a decrease in plasma albumin and edema, which is the most common reason; 2、 Diabetic patients with severe heart failure, congestion in peripheral veins, decreased blood flow back to the heart, and edema may also occur; 3、 Abnormal liver function caused by any reason reduces the ability of liver to synthesize protein. Diabetic patients are often prone to be accompanied by viral hepatitis, alcoholic liver disease, autoimmune liver disease, etc., which may lead to hypoproteinemic edema; 4、 Diabetic patients with hypothyroidism will lead to mucinous edema of the whole body; 5、 If diabetic patients take thiazolidinedione antidiabetic drugs, or combine with hypertension, use CCB antihypertensive drugs, they may have drug-induced edema.