Severe cough in the middle of the night may be related to factors such as tracheospasm and dryness, and can be improved by antihistamines or atomized medication. Cough occurs in the middle of the night, which may be related to night tracheospasm on the one hand, dry air at night, lack of moisture in the airway and other factors on the other hand. Therefore, on the one hand, antihistamines such as cetirizine and chlorphenamine maleate can be given symptomatic treatment to reduce airway sensitivity. On the other hand, we can also consider the use of atomized medication before sleep, such as oral inhalation of budesonide, propyl bromide and other drugs to reduce airway sensitivity and expand the bronchi, which may improve the cough symptoms in the middle of the night. During the treatment, pay attention to rest and avoid the intake of spicy and irritant food, otherwise the cough symptoms may be aggravated.