After the diagnosis of pulmonary tuberculosis, chemotherapy should be used first, and other treatment methods, such as symptomatic treatment, surgical treatment, are all auxiliary treatment. The goal of chemotherapy is not only to sterilize and prevent drug resistance, but also to ultimately sterilize and prevent and eliminate recurrence. At present, the internationally recognized principle of chemotherapy is early, combined, moderate, regular and full course. Compared with other types of bacterial infections, the treatment of tuberculosis may take longer. For active pulmonary tuberculosis, anti tuberculosis drugs should be taken for at least 6-9 months. The specific drugs and treatment time depend on the patient's age, overall health status and drug resistance. Common drugs include isoniazid, rifampicin, pyrazinamide, ethambutol, etc. In addition, the whole process supervision and chemotherapy management strategy should be implemented during the treatment. During the treatment of tuberculosis patients, each medication must be carried out under the direct supervision of medical personnel or trained family supervisors. Remedial measures must be taken when the drug is not used for some reason, so as to ensure that the drug is used according to the doctor's order. This way can improve the treatment compliance and cure rate, and reduce the occurrence of multidrug resistance cases.