The causes of large joint pain may be rheumatic arthritis, rheumatoid arthritis, osteoarthritis, osteoporosis, etc. First, rheumatic arthritis: rheumatic arthritis is the joint symptom of rheumatic fever disease caused by streptococcal infection, which generally involves large joints. In the acute phase, red, swollen, hot, and painful may occur. After treatment, there is generally no deformity left, and most of them occur in children. Second, rheumatoid arthritis: Although rheumatoid arthritis is easy to involve small joints, it can also cause swelling and pain in large joints. Third, osteoarthritis: Osteoarthritis is a degenerative disease of joints, which mostly involves weight-bearing joints, such as the knee joint and other large joints can also be involved. Fourth, osteoporosis: osteoporosis can cause pain in the whole body, mainly pain and cold pain, but also pain in large joints and small joints. Therefore, if there is pain in the large joints, go to the Rheumatology and Immunology Department of the regular hospital in time to find out the cause before treatment.