The main reason for the ulceration of the glans urethra is the infection, inflammation, trauma, canceration and other conditions at the genital area. Sometimes, when the skin disease affects the genital area, it may lead to the ulceration of the glans tissue. In addition, ulcers at the glans urethra may be caused by unclean sex life, or bacteria infection caused by not paying attention to personal hygiene. If there is an ulcer at the glans urethra orifice, it can be smeared with anti-inflammatory drugs under the guidance of a professional doctor. During the treatment, keep the penis clean. It is recommended to wear loose and comfortable cotton underpants. The washed underpants can be sterilized by sun exposure.