On May 8, the Beijing News announced the latest research results of our research team, which attracted attention.
The team completed the world's first autologous regenerative islet transplantation, This means that diabetes is no longer an incurable disease.
350 million diabetics around the world have regained hope of cure, At the same time, this breakthrough will also attract 53 trillion yuan of market for China.
Just, An American company next door is still making a lot of money in the market by relying on diet pills, I'm afraid I can't smile at all
The information in this article comes from the official media (CCTV's "The world's first diabetic patient gets rid of exogenous insulin through pig islet transplantation", Sina Finance's "25 year history of diabetes patients were cured and attracted attention, experts: the results are preliminary, research needs to be continued", China's news network's "The world's first successful autologous regenerative islet transplantation, 25 year history of diabetes patients were cured") , but in order to improve the readability of the article, the details may be polished, please read rationally for reference only!
New achievements cause a sensation
as report goes, The world's first autologous regenerative islet transplantation was completed by the research team of Shanghai Long March Hospital, The leader is Professor Yin Hao. As early as the end of April this year, Yin Hao had worked with the Cheng Xin team of the Center for Excellence and Innovation in Molecular Cell Science of the Chinese Academy of Sciences, This research achievement was published in the international academic journal Cell Discovery.
Autologous regenerated islets, Endodermal stem cells are derived from stem cells in diabetic people, Also known as in vitro islet reconstruction. Although the operation is simple, the process is quite complicated, Because researchers must first remove the impurities in the patient's stem cells. Only after the separation operation is completed, can the autologous regenerated islets of langerhans survive effectively, thus helping diabetics to achieve recovery.
The first recipient of autologous regenerative islet transplantation in the world, He is a male patient with a 25 year history of type 2 diabetes. In June 2017, the patient changed from uremia to end-stage diabetic nephropathy, He received a kidney transplant. Although the operation was successful, the patient still had the risk of recurrence of diabetes and had to rely on insulin to control the condition for a long time.
Treatment of diabetes is expensive, The repeated operation has increased the financial burden of the patient's family, Extreme physical and mental suffering. Fortunately, in July 2021, This male patient received autologous islet reconstruction transplantation in Shanghai Long March Hospital, Things are beginning to improve.
At the 11th week after operation, the male patient completely got rid of dependence on exogenous insulin, The dosage of oral hypoglycemic drugs such as paracetamol and metformin has also gradually decreased. At the 56th week after operation, the patient stopped drug treatment, Now it has been 33 months since he completely got rid of insulin. Now the patient has returned to normal life and is competent for work. He no longer has to suffer from illness.
This achievement made by Yin Hao's team, It caused a worldwide sensation, The majority of diabetic patients are therefore rekindling hope. However, autologous regenerative islet transplantation is mainly aimed at ordinary diabetes, In case of severe patients or fragile diabetics, This treatment may not still apply.
In addition, when autologous regenerative islet transplantation is performed, The age and gender of diabetic patients should also be taken into consideration. In this case, a 59 year old male patient was treated, It is likely that the treatment will be hindered due to the vulnerability of its own body. In this way, patients still need to spend a lot of money to see a doctor, and the result is equivalent to useless work.
Therefore, at this stage, the autologous regenerative islet transplantation proposed by Yin Hao's team still has some limitations. The types of diabetes are complex and changeable. Although male patients have made a good start, However, to promote it to the mainstream of diabetes treatment in the world, technical means need to be constantly optimized. To this end, Yin Hao's team will continue to carry out research, And strive for new breakthroughs at an early date.
There is still a long way to go
The harm of diabetes is great. Once people are infected with this disease, they will suffer from kidney failure, blindness and other complications due to poor blood sugar control, In severe cases, even death may result from ketoacidosis or unconscious hypoglycemia. In recent years, the prevalence of diabetes in the world has always been growing, reaching 530 million by 2021. In China, there are 140 million diabetics.
China is the largest country with diabetes. Among the 140 million diabetics, About 40 million patients must be accompanied by insulin for life. For some severe patients who cannot control blood sugar, minimally invasive surgery is still the main method to extract islet tissue from donated pancreas. The research results of Yin Hao's team, It is the optimization scheme proposed to solve the defects of this treatment mode.
According to the data of Pinglu, IDF, by 2045, The number of adult diabetics in the world will rise to 783 million. At the same time, the organization also predicted that the scale of medical expenditure for adult diabetics in the world would also expand, It will exceed $1 trillion by 2030. The treatment of diabetes patients cannot be separated from drug treatment. Based on this premise, some medical companies will take the opportunity to make a big profit.
The most typical is Eli Lilly, which focuses on medical care, But Leng earned 1.817 billion dollars in revenue in the first quarter of this year by selling diet pills. The weight-loss drugs researched by the company can not only help patients get rid of obesity, It can also effectively inhibit the deterioration of diabetes, This is simply "good medicine" for diabetics who must rely on drugs to regulate blood sugar.
On the other hand, Medical companies will also use patients' demand for drugs to open up markets, In order to obtain greater commercial profits. However, as Yin Hao's team successfully completed the world's first autologous islet reconstruction surgery, Diabetics' dependence on drugs will gradually decrease, Medical companies may no longer be able to take advantage of the 53 trillion yuan diabetes market.
#First article challenge#
reference material
【1】 CCTV Network "The world's first diabetic patient gets rid of exogenous insulin through pig islet transplantation";
https://news.cctv.com/2023/01/12/ARTI4XGQUJoQ3HQJEbimEdK3230112.shtml
【2】 Sina Finance's "25 year history of diabetes patients are cured, experts: the results are preliminary, and research needs to be continued";
https://finance.sina.com.cn/jjxw/2024-05-08/doc-inaupqtf7109442.shtml
【3】 The world's first successful autologous regenerative islet transplantation, cured patients with a 25 year history of diabetes
https://www.chinanews.com/life/2024/05-07/10212415.shtml
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