Highly toxic and explosive hazardous chemicals have two sides: they are indispensable means of production for relevant enterprises and institutions, and play a positive and unique role in economic and social development; It may also cause mass casualties due to poor management, which seriously endangers public security. There are rules to follow in safety management. As long as we pay attention to the thought, adopt the correct method, implement the responsibility, take effective measures, and train in place, most accidents can be completely avoided, and the safety management work can be done well. The person in charge of the unit shall, with a sense of responsibility of "always reassuring", pay close attention to the safety management of dangerous and explosive articles, practically improve the safety management level of the unit's articles, firmly hold the bottom line of safety, and practically safeguard the safety of people's lives and property.