Association of gene polymorphism of interferon-induced transmembrane protein with the extent of HBV infection
WANG Bo-wen；WANG Qiang；HUANG Yan-chun；ZHANG Ge-min；CHEN Hua；ZHU Xiong-lin；
OBJECTIVE To investigate the relationship between interferon-induced transmembrane protein（IFITM）gene polymorphism and the extent of hepatitis B virus（HBV）infection.METHODS 104 patients with HBV infection admitted to Wuhan Xinzhou District People's Hospital between Jan.2017 and Jan.2021 were selected as the study group and were divided into group A（Child-Pugh grade A，n=31），group B（Child-Pugh grade n=30）and group C（Child-Pugh grade C，n=43）according to the severity of liver function injury caused by HBV infection.90 healthy people who underwent physical examination in the hospital during the same period were enrolled as the control group.Direct sequencing was used to detect IFITM gene polymorphism，and Logistic regression analysis was used to analyze the association between IFITM3 gene polymorphism and degree of HBV infection.RESULTS The frequencies of CC genotype and C allele at the rs12252 locus of IFITM3 gene in the study group were higher than those in the control group（P<0.05）.There were statistically significant differences in the frequencies of CC genotype and C allele at the rs12252 locus of IFITM3 gene among patients with different degrees of HBV infection（P<0.05）.Logistic regression analysis showed that the risk of severe HBV infection in patients carrying CC genotype under additive mode of rs12252 locus of IFITM3 gene was 3.600 times that of patients carrying the TT genotype（P<0.05）.In the recessive mode of rs12252 locus，the risk of severe HBV infection in patients with CC genotype was 3.527 times that of patients with TT+TC genotype（P<0.05）.CC genotype at the rs12252 locus of IFITM3 gene was a risk factor for the extent of HBV infection（P<0.05）.CONCLUSION Polymorphisms at the rs12252 locus of the IFITM3 gene were associated with the degree of HBV infection，and the CC genotype might increase the risk of severe HBV infection.
