结构Biology技术

 
Protein-ligand structural elucidation challenges？
 

X-Ray or cryo-EM？

 

Our industrialised processes are tried and tested，generating over700meaningful structures per year for drug discovery.Our facilities and experts are equipped to handle even the most challenging drug targets for your strucctural elucidation.Check out what Proteros cando for you in both disciplines。

CRYO-EM

Premium，industrialized cryo-EM Facility.The cryo-EM process at Proteros has been developed and honed to reliably generate structural data.From our in-house experts in protein preparation and cryo-EM，toour range of microscopes we have the experience and technology to deliver world-ass hes GHT FASTER。

先进科学

快速、Purification and Analytics

Top-tier protein science platform to deliver the RIGHT proteins and complexes

Grid Preparation&Negative Staining

  • Grid preparation（Vitrobot Mark IV）

  • Tecnai Spirit&Phillips CM 100 microscopes access for negative staining EM screening and data collection

High-end cryo-EM microscopes

  • Glacios cryo-EM microscope with cutting-edge Falcon4direct electron detector for cryo-EM grid screening，low-and high-resolution data collection（≥3）；also access to Titan Krios（2-3埃）

X-RAY CRYSTALLOGRAPHY

特优， industrialized X-Ray Crystallography facility.We look back upon20successful years of serving the pharma and biotech drug discovery community with meaningful structures.We have optimized every single step from protein construct design down to high-resolution structure foryou.We auture automatto index pertise to provide areliable process for generating high-resolution crystallography data to help you REACH RIGHT FASTER

PROTEIN SCIENCE

快速、Purification and Analytics

Top-tier protein science platform to deliver the RIGHT protein sample

Industrialized crystallization platform

可旋转和可恢复的旋转定位
升级到2000初始crystallization conditions
自动imaging to monitor crystallization events

自由移动系统

Optimizes protein crystal diffraction characteristics。

Additional FMS modules:

    • FMS-Laser applies defined heat cycles
    • FMS-Aerosol Generator applies organic solvents or ligands
    • FMS-cryo Switch gently freezes crystals

DATA Collection

  • 同步beamline Swiss Light Source，SLS（Paul Scherrrer Institute，Switzerland；Photo source/credit:Paul Scherrer Institute）

  • Premium Eiger2X16M detector and automatic sample changer TELL

  • 现场和远程access

结构装置

  • 数据处理和structure solution（MIR/MAD/SAD和Molecular Replacement）
    • STARANISO（Global Phasing Ltd）to enable challenging anisotropic data处理
    • 集成显卡结构数据库（CSD）

Proteros Statistics

+0

proven track record with pharma and biotech partners in US，Europe and Japan

0

employees

+0

peer-reviewed publications

+0

已保护的结构

接触Us

 

If you are interested in how Proteros can support your structural biology projects，please get in touch using the contact form below。

*预应力密封

 

CONTACT US