Structural Biology Services

Pioneer and leader in structural biology services

In-house cryo-EM and more than 7,000 X-Ray structures solved

Proteros heritage lies in Protein X-Ray structures. Based on a 30 years academic history, rewarded by a Nobel Prize of Prof. Dr. Dr. Robert Huber related to protein crystallography, Proteros became one of the first service provider focusing on structural biology (please refer to "our history").

We represent a very large and well experienced X-Ray crystallography service group, covering more than 25 structural biologists, including 4 cryo-EM experts, all with a strong academic pedigree, numerous peer reviewed publications and have solved more than 7,000 structures.

Our technology platform includes co-ownership of a synchrotron beamline at the well-known Swiss Light Source and proprietary technologies (Free Mounting System) for crystal optimization.

Proteros Premium Structural Services

We offer premium X-Ray and cryo-EM services covering:

The RIGHT protein science and construct design
Crystallization, data collection, structure determination
Access to X-ray including synchrotron and in-house cryo-EM

We have an in-depth experience of successfully working with a wide range of drug targets, including:

Membrane proteins / epigenetic complexes
Protein complexes / protein-DNA/RNA complexes
Protein/lipid kinases / proteases
Biologics (Fab-Antigen structures).

X-Ray Gallery Structures

Proteros has established protein production and crystallization protocols for hundreds of targets. Search our gallery database for your target of interest.

Accelerated timelines for receipt of your desired structure!

Why Gallery Structures?

Broad access to established crystal systems
Synchrotron data collection
High success rate
Very short timelines

If your target of interest is not listed, please consider our "Gene-to-Structure" or Custom Services.

View gallery

X-ray Gene-to-Structure

Industrialized protein crystallography services with co-ownership of a synchrotron beamline for high-resolution structural elucidation.

Proteros Crystallography service can include:

Construct definition, protein production, and purification
Crystallization screening across up to 2,000 initial conditions
In-house crystal diffraction quality check
Data collection at the Swiss Light Source, SLS, industrial Beamline PXII and structure analysis
Synergistic access to in-house biophysical ligand-target interaction analyses: functional expression, protein stability, correct folding, glycosylation patterns, target-ligand affinity, kinetics and residence time.

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Cryo-EM Structures

We have already industrialized Protein X-Ray Crystallography – now we are industrializing Protein cryo-EM !

Proteros cryo-EM Service includes:

Protein preparation for cryo-EM
EM-feasibility analysis
Cryo-EM condition optimization
Low/High resolution cryo-EM structure analysis

In a project you can enter and leave the cryo-EM process at nearly any stage depending on your requirements, however we recommend our complete cryo-EM service.

With direct and instant access to protein science, grid preparation, condition optimisation and the latest high-resolution cryo-electron microscopes, you can be sure to REACH RIGHT FASTER for your downstream application.

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FIND A Gallery STRUCTURE

Proteins, Structures and Assays

Select an option:

Variant Catalog No SwissProtID

VIEW ALL GALLERY PRODUCTS

Proteros X-Ray & cryo-EM Technology

Proteros X-Ray Crystallography Technology Access

Robotics for efficient and reliable drop setting
2,000 initial crystallization conditions (based on 20 years+ experience and refinement)
Automated systems to monitor crystallization events + integrated database
Proprietary Free Mounting System (FMS-Laser, FMS-Aerosol Generator, FMS-cryo switch)
In-house, highly brilliant rotating anode X-ray generator (FRE-plus Rigaku)
Proprietary automated pipeline for data processing and structure solution (MIR/MAD/SAD and Molecular Replacement)
Remote and on-site access to high brilliance industrial undulator beamline PXII (X10SA) at Swiss Light Source
Member of the GlobalPhasing consortium

Proteros cryo-EM Technology Access

Vitrobot Mark IV
Tecnai Spirit and Phillips CM100 negative staining EM microscopes
Glacios cryo-EM microscope with high-end Falcon 4 detector
Access to Titan Krios cryo-EM high resolution cryo-EM microscopy

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X-RAY CRYSTALLOGRAPHY

Learn about our Crystallography platform

CRYO-EM

Learn about our cryo-EM platform

Our structural biology track record

Proteros has a continuous track record of more than two decade with global Pharma and Biotech in the USA, Europe, and AP, unlocking technically demanding and novel targets for small molecule drug discovery.

Uncovered more than 250 different targets over the last 3 years including membrane proteins, epigenetic protein complexes, RNA/DNA binding proteins, proteases, kinases, phosphatases and lipases
Completed more than 6,000 structural biology projects, averaging 700+ meaningful and valuable structures per year for drug discovery research
200+ Gallery Structures established with defined protein production and crystal condition recipes for swift Protein-Ligand structure determination
Our project success rate is >90% in terms of quality, reaching milestones and timelines

Structural Biology

Pioneer and leader in structural biology services

Proteros Premium Structural Services