结构Biology

Pioneer in structural biology services

In-house cryo-EM and more than7000X-Ray structures solved

Proteros heritage lies in Protein X-Ray structures.Based ona30years academic history，rewarded by a Nobel Prize of Prof.Dr.Robert Huber related to protein crystallogaphy，Proteros became one of the first service provider focusing on structural biology（please refer to“our history”）。

We represent a very large and well experienced X-Ray crystallography service group，covering more than25 structural biologists，including4cryo-EM experts，all with a strong academic pedigree，numerous peer reviewed publications and have solved more than7000structures。

Our technology platform includes co-ownership of a synchrotron beamline at the well-known Swiss Light Source and proprietary technologies（Free Mounting System）for crystal optimization。 

专业特优结构服务

We offer premium X-Ray and cryo-EM services covering：

  • The RIGHT protein science and construct design
  • Crystallization，data collection，structure determination
  • 接入到X-ray including synchrotron and in-house cryo-EM
施工现场布置，施工现场布置：
  • Membrane proteins/epigenetic complexes
  • Protein complexes/protein-DNA/RNA complexes
  • 保护/保护kinases/proteases
  • Biologics（Fab-Antigen structures）。

FIND A Gallery STRUCTURE

结构和装配

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结构Biology Services

高强度再solution of Elucidation of even the most complex structures through the delivery of the RIGHT protein and application of high-resolution生产性crystallography and cryo-EM

X-Ray Gallery Structures

Proteros has established protein production and crystallization protocols for hundreds of targets.Search our gallery database for your target of interest。

Accelerated timelines for receipt of your desired structure！

Why Gallery Structures？
  • Broad access to established crystal systems
  • 同步数据检测
  • 高通量额定值
  • Very short timelines

If your target of interest is not listed，please consider our“Gene-to-Structure”or Custom Services。

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SLS Syncrotron_NTCG-1

Photo source/credit:Paul Scherrer Institute

X-ray Gene-to-Structure

Industrialized protein crystallography services with co-ownership of a synchrotron beamline for high-resolution structural elucidation

Proteros Crystallography service can include：
  • 构建说明，产品说明，和产品说明
  • Crystallization screening across up to 2000初始conditions
  • 内部crystal diffraction quality check
  • 数据collection at the Swiss Light Source，SLS，industrial Beamline PXII and structure analysis
  • Synergistic access to in-house biophysical ligand-target interaction analyses:functional expression，protein stability，correct folding，glycosylation patterns，target-ligand affinity，kinetics and residence time。
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Cryo-EM结构

We have already industrialized Protein X-Ray Crystallography–now we are industrializing Protein cryo-EM！

Proteros cryo-EM Service includes：
  • 生产用预应力混凝土
  • EM-feasibility分析
  • Cryo-EM condition optimization
  • 低/高分辨率分析
In a project you can enter and leave the cryo-EM process at nearly any stage depending on your requirements，however we recommend our complete cryo-EM service。
 
With direct and instant access to protein science，grid preparation，condition optimisation and the latest high-resolution cryo-electron microscopes，you can be sure to REACH RIGHT FASTER for your downstream application。

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Proteros X-Ray&cryo-EM Technology

Proteros X-Ray Crystallography Technology Access

  • 可旋转和可恢复的旋转定位
  • 2000初始crystallization conditions（based on 20 years+experience and refinement）
  • 自动系统到monitor crystallization events+integrated database
  • FMS-Laser，FMS-Aerosol Generator，FMS-cryo switch）
  • In-house，highly brilliant rotating anode X-ray generator（FRE-plus Rigaku）
  • 数据处理和structure solution（MIR/MAD/SAD和Molecular Replacement）
  • Remote and on site access to high brilliance industrial undulator beamline PXII（X10 SA）at Swiss Light Source
  • 成员的全球Phasing consortium

专业技术访问
  • Vitrobot Mark IV
  • Tecnai Spirit and Phillips CM 100 negative staining EM microscopes
  • Glacios cryo-EM microscope with high-end Falcon4 detector
  • 接入到Titan Krios cryo-EM high resolution cryo-EM microscopy
夹头，夹头

X-RAY CRYSTALLOGRAPHY

Learn about our Crystallography platform

CRYO-EM

Learn about our cryo-EM platform

欧氏双轨record


Proteros has a continuous track record of more than two decade with global Pharma and Biotech in the USA，Europe，and AP，unlocking technically demanding and novel targets for small molecule drug discovery。

  • Uncovered more than250different targets over the last3years including membrane proteins，epigenetic protein complexes，RNA/DNA binding proteins，proteases，kinases，phosphatases and lipases
  • Completed more than6000 structural biology projects，averaging700+meaningful and valuble structures per year for drug discovery research
  • 200+Gallery Structures established with defined protein production and crystal condition recipes for swift Protein-Ligand structure determination
  • our project success rate is>90%in terms of quality，reaching milestones and timelines

结构工具？

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To learn more about Structural Biology，contact us below。

*预应力密封

 

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