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Genotype Screening in Songbirds Made Easy

February142023

974

Christien Bowman，MSc，has traversed a path from psychology to neuroscience，and is now working on attaining his PhD in biomedicine.In this interview， we discussed how Bowman uses Chelex100 Resin as part of a fast and cost-effective method to determine the sex of zebra finch songbirds.This work ultimatimately helps Bowman study a behavioral paradigm that creates autism-like features in songbirds。

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A Pioneering Approach to Biotherapeutic Antibody Discovery

October 112022

Immunotherapy has revolutionized cancer treatment，yet the drug discovery process to develop new biotherapeutic antibodies remains arduous.However，significant advances in antibody technology such as phage display have enabled fully human antibodies to be developed franimal-free libries for jabogen。

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Scientists for Life:A Tale of Two Tattoos

January112022

13.5k

ast scientists，no matter where they are at in their career，remember the moments of wonder as they navigated lab work for the first time.Whether it’s a band on a gel，a colony on a plate，or a piece of data，those first tangible results come with a feeling of having accomplished something increds，ithere in， we caught up with two scientists who immortalized that feeling in the form of matching protein ladder tattoos，and discussed howtheir time asundergraduate researchers led them where they are today。

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6层到截面Funding for Flow Cytometers

June82021

1.6k

We asked core facilities staff and research scientists from the U.S.and Europe for their top tips for securing funding for large instrumentation，such as a cell analyzer or cell sorter.Here are the key questions you should consider while preparing your grant application to increase your chances of a successful outcome。

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Immune Surveillance in SARS-CoV-2 Vaccine Development

March82021

1.2k

The ability to characterize the target of cell-mediated immune response is crucial during vaccine development.In studying the characterization of SARS-CoV-2 infection pathogenesis in humans， aresearch team identified neutralizing antibodies that provided context for vaccine antigen design.Discover how the ZE5 Cell Analyzer was used to detect activativation-induced markers，measure intracellular cytokines，and identify spike protein–specific antibodies in a rapid，high-throughnermanput。

Articles COVID-19 Droplet Digital PCR（ddPCR）Featured Stories 通用接口

从顶部水采暖器

December8200

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The COVID-19pandemic has captured the attention of the world and won’t let go.And that has sparked effor creative solutions in some surprising places.Wastewater is not where most peoples’minds go first when they think of airborne diseases，but it holds much promise for tracing and redictRS-Corges。

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A New International Standard to Measure DNA？

September92020

1.8k

From quantifying a patient’s tumor DNA to counting the viral load of an individual infected with COVID-19，the breadth of digital PCR（dPCR）applications continues to grow and fulfill critical scientific needs。dPCR offers the ability to count nucleic acid molecules directly，rather than extrapolating the quantity from standard curves as with many other methods.By harmonizing diagnostic procedures on dPCR platforms，the scientific and medical communities can become more core cordinated and efficient。

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10 Tips为Setting Up a Successful Cell Sorting Experiment

June10220

7.9k

Incorporating fluorescence-based cell sorting intoyour lab grants you powerful access to new research areas and rarer cell types without sacrificing efficiency or results.New， powerful techniques like CRISPR and single-cell analysis are enhanced by the isolation of specific cells.But isolating cell populations of the right quality and quantity is both challenging and time consuming.We offer some tips to set yourself up for success and get the most out of your sorts。

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Improving CRISPR-Cas9 Gene Editing:
HDR Inefficiency Problem

March112020

4.5k

arecent publication showed that expression of a protein involved in homology-directed repair（HDR）can improve efficiency of CRISPR-Cas9gene editing。Learn how manipulation of DNA repair pathways and improvements to gene editing workflows，such as the addition of cell sorting，can facilitate applications of CRISPR-Cas9technology。

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Active Machine Learning in Drug Discovery

February12200

1.2k

Drug discovery and development are both time and resource intensive since a lot of different compounds need to be screened across a lot of different targets.See how machine learning models can be used to predict screening results and how active learning algorithms can be used to efficiently septh expertiment toose models。