BRPFs（bromodomain and PHD finger-containing proteins）are multidomain proteins of the Trithorax group（TrxG）：regulatory proteins composed of diverse，evolutionary conserved units that form chromatin-associated complexes accounting for电子传输量.Three BRPFs are known to date，sharing>65%homology in their~100amino acid counting sequences，all sharing an acetylated lysine（KAc）recognition site that closely resembles other bromodomains，including those of theBETs[1].BRPF1（also known as Br140 and Peregrin）is a component of complexes containing the MOZ/MORF transcriptional coactivators，that links the catalytic HATs to the other subunits ING5and hEAF6.Furthermore，BRPF1contains PHD fingers，a bromodomain and a PWWP domain[2].It has been shown that BRPF1has a central role during development，since mutations have shown to display anterior transformations of pharyngeal arches due to progressive loss of anterior Hox gene expression.What’s more，translocations of MOZ are associated with aggressive subtypes of leukemia，and make BRPF1an interesting target in oncology related research[3]。