IN 1130

Based on 20 reference(s) in Google Scholar 80 100 20

Axon2236

CAS [868612-83-3]

MF C25H20N6O
MW 420.47

Purity:99%
Soluble in DMSO

IN 1130

Description

Highly selective small molecule ALK5 inhibitor (IC50 value of 5.3 nM for inhibition of ALK5-mediated Smad3 phosphorylation) with >100 fold selectivity over p38α and a panel of 26 other serine/threonine and tyrosine kinases. Suppressor of fibrogenic process of unilateral ureteral obstruction in rats underscoring the potential clinical benefits in the treatment of renal fibrosis. By inhibition of TGF-β signaling, IN1130 ameliorated experimental autoimmune encephalomyelitis, lessened tunical fibrosis and corrected penile curvature in rats, inhibited cancer metastasis in MMTV/c-Neu breast cancer mice, and enhanced CTL response in cancer mice.

C.Y. Park et al. An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition. Cancer Lett. 2014 Aug 28;351(1):72-80.

C.H. Jin et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Bioorg Med Chem. 2011 Apr 15;19(8):2633-40.

J.A. Moon et al. IN-1130, a novel transforming growth factor-bold italic beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney International (2006) 70, 1234–1243.

G.T. Lee et al. Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/activin receptor-like kinase-5, on prostate cancer cells. J Urol. 2008 Dec;180(6):2660-7.

J.K. Ryu et al. IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature.... J Sex Med. 2009 May;6(5):1284-96.

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class I; EC 2.7.11.30 TGF-βR

TGF-βR 1 inhibitor

Chemical name

3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide

Parent CAS No.

[868612-83-3]

Order

Size	Unit Price	Stock
5 mg	€95.00	In Stock
25 mg	€350.00	In Stock

Need more?Bulk Inquiry

Related Products

Axon ID	Name	Description
1387	SD 208	TGF-βR 1 inhibitor	€50.00
1421	A 83-01	TGF-βR 1 inhibitor; ALK 5 inhibitor	€70.00
1491	LY 2157299	TGF-βR2 inhibitor	€60.00
1661	SB 431542	TGF-βR1 inhibitor; ALK inhibitor	€70.00
1744	A 77-01	TGF-βR 1 inhibitor; ALK 5 inhibitor	€80.00
1832	GW 788388	TGF-βR 1 inhibitor	€50.00
2197	SB 505124	Selective inhibitor of TGF-β type I receptors ALK4 and ALK5	€95.00
2285	SB 525334	Potent and selective inhibitor of the TGF-βR1 (ALK5) receptor	€105.00
2323	ITD 1	Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis	€105.00
2426	SMURF1 inhibitor A01	Inhibitor of E3 ubiquitin-protein ligase SMURF1	€115.00
2647	Pirfenidone	Broad-spectrum anti-inflammatory and anti-fibrosis agent	€60.00
2764	SIS3	Potent and selective inhibitor of Smad3 and TGF-βR1 signaling	€135.00
2943	SRI-011381 hydrochloride	TGF-β signaling agonist	€125.00
3076	TJ191	Potent and selective anti-cancer agent targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells	€120.00
3404	LY-364947	Potent, selective and ATP-competitive TGF-βR 1 inhibitor	€90.00
3892	LY-3200882	TGF-βR 1 inhibitor	Inquire
3971	CCT196969	Paradox-breaking pan RAF Inhibitor	Inquire
4168	BMS-986260	Potent, selective and orally bioavailable TGF-βR 1 inhibitor	€120.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

IN 1130

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

IN 1130

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us