最新biologics drug discovery approaches today look to existing antibody libraries for incremental improvements.We recently showed how we designde novoantibodies“from scratch”on a computer.Our zero-shot AI approach designs antibodies without prior learning on the specific target,generating candidates unlike those found in existing databases.Our wet lab can experimentally validate the candidate s that work right out of the computer-without the slow and costly step of lead optimization.This potentially reduces the time it takes to get new drug leads into the clinic,while unlocking treatments for traditionally“undruggable”diseases and improved therapeutic possibilities for many others。