A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

doi:10.3390/vaccines7020037

Review

。2019Apr24；7（2）：37。

doi:10.3390/vaccines7020037。

Plasmid DNA and mRNA as Vaccine Technologies

Margaret A Liu^1个

疲劳，疲劳

PMID: 31022829
PMCID: PMC6631684
DOI: 10.3390/vaccines7020037

Review

Plasmid DNA and mRNA as Vaccine Technologies

Margaret A Liu。 Vaccines（Basel）。 2019。

。2019Apr24；7（2）：37。

doi:10.3390/vaccines7020037。

Author

Margaret A Liu^1个

空气净化

^1个ProTherImmune，3656Happy Valley Road，Lafayette，CA94549，USA。Liu@ProTherImmune.com。

PMID: 31022829
PMCID: PMC6631684
DOI: 10.3390/vaccines7020037

Abstract

This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies.While both have been under development since the 1990s，in recent years， significant excitement has turned to mRNA despite the licensure of several veterinary DNA vaccines.Both have required efforts to increase their potency either via manipulating the plasmid DNA and the mRNA directly or through the addition of adjuvants or immunomodulators as well as delivery systems and formulations and formations in ammateamentry nature of the mRNA vaccines is discussed for both its potential immunological utility for vaccines and for the potential toxicity.The status of the clinical trials of mRNA vaccines is described along with a comparison to DNA vaccines， specifically the immunogenicity of both licensed veterinary DNA vaccines and select DNA vaccine candidates in human clinical trials。

Keywords:Cytolytic TLymphocytes；DNA vaccine；antibodies；formulations；immune responses；in vitro transcribed mRNA；innate immunity；mRNA vaccine；plasmid DNA。

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“The author declares no conflict of interest.”

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参考，参考

1. Liu M.A.DNA vaccines:An historical perspective and view to the future.Immunol.Rev.2011；239:62-84.doi:10.11111/j.1600-065X.2010.00980.x。-是的DOI-是的PubMed
1. Pardi N.，Hogan M.J.，Porter F.W.，Weissman D.mRNA vaccines––––Anewera in vaccinology.Nat.Rev.Drug Discov.2018；17:261-279.doi:10.1038/nrd.2017.243。-是的DOI-是的PMC-是的PubMed
1. Stevenson F.K.，Zhu D.，King C.A.，Ashworth L.J.，Kumar S.，Hawkins R.E.Idiotypic DNA vaccines against B-cell lymphoma.Immunol.Rev.1995；145:211–228.doi:10.11111/j.1600-065X.1995.tb00083.x。-是的DOI-是的PubMed
1. Syrengelas A.D.，Chen T.T.，Levy R.DNA immunization induces protective immunity against B-cell lymphoma.Nat.Med.1996；2:1038-1041.doi:10.1038/nm0996-1038。-是的DOI-是的PubMed
1. Sahin U.，KarikóK.，TüreciÖ。mRNA-based therapeutics–––Developing a new class of drugs.Nat.Rev.Drug Discov.2014；13:759-780.doi:10.1038/nrd4278。-是的DOI-是的PubMed

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[1] Liu M.A.DNA vaccines:An historical perspective and view to the future.Immunol.Rev.2011；239:62-84.doi:10.11111/j.1600-065X.2010.00980.x。-是的DOI-是的PubMed

[2] Liu M.A.DNA vaccines:An historical perspective and view to the future.Immunol.Rev.2011；239:62-84.doi:10.11111/j.1600-065X.2010.00980.x。-是的DOI-是的PubMed

[3] Pardi N.，Hogan M.J.，Porter F.W.，Weissman D.mRNA vaccines––––Anewera in vaccinology.Nat.Rev.Drug Discov.2018；17:261-279.doi:10.1038/nrd.2017.243。-是的DOI-是的PMC-是的PubMed

[4] Pardi N.，Hogan M.J.，Porter F.W.，Weissman D.mRNA vaccines––––Anewera in vaccinology.Nat.Rev.Drug Discov.2018；17:261-279.doi:10.1038/nrd.2017.243。-是的DOI-是的PMC-是的PubMed

[5] Stevenson F.K.，Zhu D.，King C.A.，Ashworth L.J.，Kumar S.，Hawkins R.E.Idiotypic DNA vaccines against B-cell lymphoma.Immunol.Rev.1995；145:211–228.doi:10.11111/j.1600-065X.1995.tb00083.x。-是的DOI-是的PubMed

[6] Stevenson F.K.，Zhu D.，King C.A.，Ashworth L.J.，Kumar S.，Hawkins R.E.Idiotypic DNA vaccines against B-cell lymphoma.Immunol.Rev.1995；145:211–228.doi:10.11111/j.1600-065X.1995.tb00083.x。-是的DOI-是的PubMed

[7] Syrengelas A.D.，Chen T.T.，Levy R.DNA immunization induces protective immunity against B-cell lymphoma.Nat.Med.1996；2:1038-1041.doi:10.1038/nm0996-1038。-是的DOI-是的PubMed

[8] Syrengelas A.D.，Chen T.T.，Levy R.DNA immunization induces protective immunity against B-cell lymphoma.Nat.Med.1996；2:1038-1041.doi:10.1038/nm0996-1038。-是的DOI-是的PubMed

[9] Sahin U.，KarikóK.，TüreciÖ。mRNA-based therapeutics–––Developing a new class of drugs.Nat.Rev.Drug Discov.2014；13:759-780.doi:10.1038/nrd4278。-是的DOI-是的PubMed

[10] Sahin U.，KarikóK.，TüreciÖ。mRNA-based therapeutics–––Developing a new class of drugs.Nat.Rev.Drug Discov.2014；13:759-780.doi:10.1038/nrd4278。-是的DOI-是的PubMed

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Plasmid DNA and mRNA as Vaccine Technologies

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Plasmid DNA and mRNA as Vaccine Technologies

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