Abstract

Nucleation from an aqueous solution is an important step in crystallization which controls the physicochemical properties of crystalline materials.Although dense liquid droplets are considered as precursor of a crystal in the two-step nucleation model, their actual role is unclear.Our in-situ microscopic observations of the crystallization of DL-alanine from adense liquid droplet trapped by laser tweezers show that liquid droplets play the role of a substrate,facilitating heterogeneous nucleation,rather than precursor of a crystal。

The crystallization from the laser-trapped dense liquid droplet of DL-alanine occurred at the interface between the droplet and solution toward outside of the droplet rather than inside of it.This suggests that the dense liquid droplet plays the role of substrate for heterogeneous nucleation site than dirather than rean dirs of recrys。
Graphical Abstract

The crystallization from the laser-trapped dense liquid droplet of DL-alanine occurred at the interface between the droplet and solution toward outside of the droplet rather than inside of it.This suggests that the dense liquid droplet plays the role of substrate for heterogeneous nucleation site than dirather than rean dirs of recrys。

DL-alanine单击功能区上,laser trapping单击功能区上,双步循环
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