The most common schemes for for forming a well-defined heteroconjugate involve the indirect coupling of an amine group on one biomolecule to a thiol group on a second biomolecule，usually by a two-or three-step reaction sequence with Crosslinking Reagents（Maleimido-Alkyl-Carboliacidc acids）。Introductional crosslinkers by Kratz，F.and coworkers[Bioconjugate Chem。2003,14（2），377-387.]will enhance their water solubility.Now SpeedChemical can offer these Maleimido-Poly（Ethylene Glycol）Propionic（or Acetic）Acids products to medicinal chemists and biotechnological chemists。Such asMaleimido-Tri（Ethylene Glycol）Propionic Acis，SP-19070，CAS#518044-40-1.Please see our产品段for details。
参考：
（2）Bayer Pharma Aktiengesellschaft:Novel antibody-peptide drug conjugates（ADCs）and their use and preparation。Lerchen，H.-G.；Hammer，S.；Harrenga，A.；Kopitz，
C。C。；Nising，C.F.；Sommer，A.；Stelte-Ludwig，B.；Mahlert，C.；Schuhmacher，J.；Golfier，S.；et alWO2013087716打开；WO2012143497。
（3）Pfizer Inc.：Engineered antibody constant regions for site-specific conjugation with therapeutic and for treatment of cancer，autoimmune，inflammatory，infectious or
other disease。Marquette，K.；Bennett，E.；Tchistiakova，L.；Tumey，N。WO2013093809。
