ATF4(L) floxed mice have loxP sites flanking exons 2-3 of the ATG site of the activating transcription factor 4 (Atf4) gene, including the ATG site. Atf4 encodes a transcription factor involved in mediating many cellular processes including as endoplasmic reticulum stress, osteoblastic differentiation, collagen synthesis, glucose and lipid metabolism, and vascular calcification. Mice that are homozygous for this floxed allele are viable and fertile. When bred to mice that express tissue-specific Cre recombinase, resulting offspring will have exons 2-3 deleted in the cre-expressing tissues.

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ATF4(L) floxed mice have loxP sites flanking exons 2-3 of the ATG site of the activating transcription factor 4 (Atf4) gene. These mice may be useful when studying the role of ATF4 on cellular processes effected by endoplasmic reticulum stress.

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