{“id”:“https://openalex.org/W4391094674“,”doi“:”https://doi.org/10.1371/journal.pcbi.1011828“,”title“:“用于生物标记物发现和验证的结直肠癌公共蛋白质组数据集的集成meta-analysis”,“display_name”:“用于生物学标记物发现与验证的结肠癌公共蛋白质组集的集成meta-analyse”,“publication_year”:2024,“publitation_date”:“2024-01-22”,“ids”:{“openalex”:“https://openalex.org/W4391094674“,”doi“:”https://doi.org/10.1371/journal.pcbi.1011828“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/38252632“},”language“:”en“,”primary_location“:{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1371/journal.pcbi.1011828,“pdf_url”:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011828&type=可打印,“源”:{“id”:https://openalex.org/S86033158“,”display_name“:”PLoS Computational Biology“,”issn_l“:”1553-734X“,”isn“:[“1553-734 X”,”1553-73 58“],”is_oa“:true,”is-in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310316756“,”“host_organization_name”:“国际计算生物学学会”,“host_ordanization_lineage”:[“https://openalex.org/P4310316756“],”host_organization_lineage_names“:[”国际计算生物学学会“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”type“:”article“,”type_crossref“:“journal-article”,”indexed_in“:[”crossref“,”publimed“],”open_access“:{”is_oa“:true,”oa_status“:”gold“,”oa_url“:”https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011828&type=可打印“,”any_repository_has_fulltext“:false},”authorships“:[{”author_position“:”第一“,”作者“:{”id“:”https://openalex.org/A5011603865“,”display_name“:”哈维尔·罗伯斯“,”兽人“:”https://orcid.org/0000-0002-8438-5942},“机构”:[{“id”:https://openalex.org/I4210147680“,”display_name“:”生物研究中心\u00f3gicas Margarita Salas“,”ror“:”https://ror.org/04advdf21“,”国家代码“:”ES“,”类型“:”设施“,”沿袭“:[”https://openalex.org/I134820265","https://openalex.org/I4210147680“]},{”id“:”https://openalex.org/I134820265“,”display_name“:”Consejo Superior de Investigaciones Cient\u00edficas“,”ror“:”https://ror.org/02gfc7t72“,”country_code“:”ES“,”type“:“政府”,”世系“:[”https://openalex.org/I134820265“]}],”国家“:[”ES“],”is_corresponding“:true,”raw_author_name“:”哈维尔·罗伯斯“,”raw _ afiliation_strings“:[“分子生物医学部,生物研究中心\u00f3gicas Margarita Salas,Consejo Superior de Investigaciones Cient\u00edficas,马德里,西班牙”,“Protein Alternatives SL,Tres Cantos,马德里”],“afiliations”:[{“raw_affiliation_string“:“Protein Alternatives SL,Tres Cantos,Madrid,Spain”,“institution_ids”:[]},{“raw_afiliation_string”:“分子生物医学部,Centro de Investigaciones Biol\u00f3gicas Margarita Salas,Consejo Superior de Investagiones Cient\u00edficas,西班牙马德里”,“institution_id”:[”https://openalex.org/I4210147680","https://openalex.org/I134820265“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5038723062“,”display_name“:”Ananth Prakash“,”orcid“:”https://orcid.org/0000-0001-5799-9618},“机构”:[{“id”:https://openalex.org/I1303153112“,”display_name“:”欧洲生物信息学研究所“,”ror“:”https://ror.org/02catss52“,”“country_code”“:”GB“,”type“:”facility“,”lineage“:[”https://openalex.org/I1303153112","https://openalex.org/I4210138560“]}],”国家“:[”GB“],”is_corresponding“:true,”raw_author_name“:”Ananth Prakash“,”raw _ afiliation_strings“:[“欧洲分子生物学实验室\u2014欧洲生物信息学研究所(EMBL-EBI),英国剑桥Hinxton Wellcome Genome校区”],”affiliations“:[{”raw_ afiliation _string“:”欧洲分子生物学实验室\u2014欧洲生物信息学研究所(EMBL-EBI),英国剑桥Hinxton Wellcome基因组校区“,“institution_ids”:[“https://openalex.org/I1303153112“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5044603792“,”display_name“:”Juan Antonio Vizca\u00edno“,”orcid“:”https://orcid.org/0000-0002-3905-4335},“机构”:[{“id”:https://openalex.org/I1303153112“,”display_name“:”欧洲生物信息学研究所“,”ror“:”https://ror.org/02catss52“,”“country_code”“:”GB“,”type“:”facility“,”lineage“:[”https://openalex.org/I1303153112","https://openalex.org/I4210138560“]}],”国家“:[”GB“],”is_corresponding“:true,”raw_author_name“:”Juan Antonio Vizca\u00edno“,”raw_affiation_string“:[”欧洲分子生物学实验室\u2014欧洲生物信息学研究所(EMBL-EBI),Wellcome Genome Campus,Hinxton,Cambridge,United Kingdom“],”附属机构“:[{”raw_affiation_string“:”欧洲分子生物学实验室\u2014欧洲生物信息学研究所(EMBL-EBI),英国剑桥Hinxton Wellcome基因组校区“,“institution_ids”:[“https://openalex.org/I1303153112“]}]},{”author_position“:”last“,”author“:{”id“:”https://openalex.org/A5080722826“,”display_name“:”J.Ignacio Casal“,”orcid“:”https://orcid.org/0000-0003-1085-2840},“机构”:[{“id”:https://openalex.org/I4210147680“,”display_name“:”生物研究中心\u00f3gicas Margarita Salas“,”ror“:”https://ror.org/04advdf21“,”国家代码“:”ES“,”类型“:”设施“,”沿袭“:[”https://openalex.org/I134820265","https://openalex.org/I4210147680“]},{”id“:”https://openalex.org/I134820265“,”display_name“:”Consejo Superior de Investigaciones Cient\u00edficas“,”ror“:”https://ror.org/02gfc7t72“,”country_code“:”ES“,”type“:“政府”,”世系“:[”https://openalex.org/I134820265“]}],”国家“:[”ES“],”is_corresponding“:true,”raw_author_name“:”J.Ignacio Casal“,”raw _ afiliation_strings“:[“西班牙马德里生物研究中心分子生物医学部\u00f3gicas Margarita Salas,Consejo Superior de Investigaciones Cient\u00edficas”],”从属关系“:[{”raw_ afiliation _string“:”西班牙马德里Cient\u00edficas高等研究委员会分子生物医学部,Centro de Investigaciones Biol\u00f3gicas Margarita Salas“,“institution_ids”:[“https://openalex.org/I4210147680","https://openalex.org/I134820265“]}]}],”countries_disticont_count“:2,”institutions_disticent_count”:3,”corresponding_author_ids“:[”https://openalex.org/A5011603865","https://openalex.org/A5038723062","https://openalex.org/A5044603792","https://openalex.org/A5080722826“],”对应的机构ID“:[”https://openalex.org/I4210147680","https://openalex.org/I134820265","https://openalex.org/I1303153112","https://openalex.org/I1303153112","https://openalex.org/I4210147680","https://openalex.org/I134820265“],”apc_list“:{”value“:2655,”currency“:”USD“,”value_USD“:2665,”provenance“:”doaj“},”apc _payed“:”{“value”:2655、”current“:”美元“,”value_USD”:2665、“provenance”:“doaj”}、“fwci”:5.951、“has_fulltext_origin”:“pdf”、“cited_by_count”:4、“citation_normalized_percentile”:{“值”:0.999681,“is_in_top_1_percent”:真,“is_ in_top_ 10_percent:真},”cited_by_percentile_year“:{“min”:98,“max”:99},“biblio”:{卷:“20”,“issue”:“1”,“first_page”:“e1011828”,“last_page”:“e1011828“},”is_retracted“:false,”is_paratext“:false,”primary_topic“:{“id”:“https://openalex.org/T10519“,”“display_name”:“蛋白质质谱技术”,“score”:0.9991,“subfield”:{“id”:“https://openalex.org/subfields/1607“,”display_name“:”光谱学“},”字段“:{”id“:”https://openalex.org/fields/16“,”display_name“:”Chemistry“},”domain“:{”id“:”https://openalex.org/domains/3“,”display_name“:”物理科学“}},”主题“:[{”id“:”https://openalex.org/T10519“,”“display_name”:“蛋白质质谱技术”,“score”:0.9991,“subfield”:{“id”:“https://openalex.org/subfields/1607“,”display_name“:”光谱学“},”字段“:{”id“:”https://openalex.org/fields/16“,”display_name“:”Chemistry“},”domain“:{”id“:”https://openalex.org/domains/3“,”display_name“:”物理科学“}},{”id“:”https://openalex.org/T10887“,”display_name“:”基因相互作用网络分析“,”score“:0.9881,”subfield“:{”id“:”https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T11297“,”“display_name”:“癌症中铁下垂的机制和意义”,“score”:0.9853,“subfield”:{“id”:“https://openalex.org/subfields/2740“,”display_name“:”肺与呼吸医学“},”字段“:{”id“:”https://openalex.org/fields/27“,”display_name“:”Medicine“},”domain“:{”id“:”https://openalex.org/domains/4“,”display_name“:”Health Sciences“}}],”keywords“:[{”id“:”https://openalex.org/keywords/biomarker-discovery网站“,”display_name“:”生物标记发现“,”score“:0.547079},{”id“:”https://openalex.org/keywords/proteomics网站“,”display_name“:”蛋白质组学“,”score“:0.527204},{”id“:”https://openalex.org/keywords/protein-identification网站“,”display_name“:”蛋白质鉴定“,”score“:0.517388}],”concepts“:[{”id“:”https://openalex.org/C4611723,“wikidata”:https://www.wikidata.org/wiki/Q471857“,”display_name“:”蛋白质组学“,”level“:3,”score“:0.6648296},{”id“:”https://openalex.org/C2781197716,“wikidata”:https://www.wikidata.org/wiki/Q864574“,”display_name“:”Biomarker“,”level“:2,”score“:0.6048255},{”id“:”https://openalex.org/C124535831,“wikidata”:https://www.wikidata.org/wiki/Q4915074“,”display_name“:”生物标记发现“,”level“:4,”score“:0.55421627},{”id“:”https://openalex.org/C526805850,“wikidata”:https://www.wikidata.org/wiki/Q188874“,”display_name“:”结直肠癌“,”level“:3,”score“:0.49348295},{”id“:”https://openalex.org/C70721500,“wikidata”:https://www.wikidata.org/wiki/Q177005“,”display_name“:”计算生物学“,”level“:1,”score“:0.3977753},{”id“:”https://openalex.org/C60644358,“wikidata”:https://www.wikidata.org/wiki/Q128570“,”display_name“:”生物信息学“,”level“:1,”score“:0.38518786},{”id“:”https://openalex.org/C71924100,“wikidata”:https://www.wikidata.org/wiki/Q11190“,”display_name“:”Medicine“,”level“:0,”score“:0.35625678},{”id“:”https://openalex.org/C41008148,“wikidata”:https://www.wikidata.org/wiki/Q21198“,”display_name“:”计算机科学“,”level“:0,”score“:0.3520308},{”id“:”https://openalex.org/C121608353,“wikidata”:https://www.wikidata.org/wiki/Q12078“,”display_name“:”Cancer“,”level“:2,”score“:0.29632205},{”id“:”https://openalex.org/C86803240,“wikidata”:https://www.wikidata.org/wiki/Q420“,”display_name“:”生物学“,”等级“:0,”分数“:0.22349161},{”id“:”https://openalex.org/C12632202,“wikidata”:https://www.wikidata.org/wiki/Q11180“,”display_name“:”内科“,”level“:1,”score“:0.15225178},{”id“:”https://openalex.org/C104317684,“wikidata”:https://www.wikidata.org/wiki/Q7187“,”display_name“:”Gene“,”level“:2,”score“:0.0789628},{”id“:”https://openalex.org/C55493867,“wikidata”:https://www.wikidata.org/wiki/Q7094“,”display_name“:”生物化学“,”level“:1,”score“:0.0}],”mesh“:[{”descriptor_ui“:”D014408“,”描述符名称“:”生物学标记,肿瘤“,”限定符_ui”:“Q000378”,”限定词名称“:“新陈代谢”,”is_major_topic“:false},{”描述符名称,{“descriptor_ui“:”D015179“,”descriptor_name“:”大肠肿瘤“,”qualifier_ui”:“Q000175”,“qualifier _name”:“diagnosis”,“is_major_topic”:false},{“descriptor_ ui”:“D006801”,“descriptor _name”:“Humans”,“qualifier _ui(限定符_ ui):“”,“限定符_ name”:null,“is_ major_topic”:false},{”descriptor _ui:“D019704”,“描述符_名称”:“蛋白质二硫酶-Isomerases”,“qualifier_ui“:”“,”qualifier_name“:null,”is_major_topic“:false},{”descriptor_ui“:”D040901“,”descriptor_name“:”蛋白质组学“,”qualifier_ui“:”“,”qualifier_name“:null,”is_major_topic“:false}],”locations_count“:2,”locations“:[{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1371/journal.pcbi.1011828,“pdf_url”:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011828&type=可打印,“源”:{“id”:https://openalex.org/S86033158“,”display_name“:”PLoS Computational Biology“,”issn_l“:”1553-734X“,”isn“:[“1553-734 X”,”1553-73 58“],”is_oa“:true,”is-in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310316756“,”“host_organization_name”:“国际计算生物学学会”,“host_ordanization_lineage”:[“https://openalex.org/P4310316756“],”host_organization_lineage_names“:[”国际计算生物学学会“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},{”is_oa“:false,”landing_page_url“:”https://pubmed.ncbi.nlm.nih.gov/38252632“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false}],“best_oa_location”:{“is_oa”:true,“landing_page_url”:“https://doi.org/10.1371/journal.pcbi.1011828,“pdf_url”:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011828&type=可打印,“源”:{“id”:https://openalex.org/S86033158“,”display_name“:”PLoS Computational Biology“,”issn_l“:”1553-734X“,”isn“:[“1553-734 X”,”1553-73 58“],”is_oa“:true,”is-in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310316756“,”“host_organization_name”:“国际计算生物学学会”,“host_ordanization_lineage”:[“https://openalex.org/P4310316756“],”host_organization_lineage_names“:[”国际计算生物学学会“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”sustainable_development_goals“:[],”grants“:{”funder“:”https://openalex.org/F4320313831“,”“funder_display_name”:“马德里社区”,“award_id”:“IND2019/BMD-17153”},{“funder”:“https://openalex.org/F4320314023“,”“funder_display_name”:“欧洲分子生物学实验室”,“award_id”:null},{“funder”:“https://openalex.org/F4320322930“,”funder_display_name“:”Ministerio de Ciencia e Innovaci\u00f3n“,”award_id“:”RTI2018-095055-B-I00,PID2021-122227OB-I00和PDC2022-133056-I00“},{”funder“:”https://openalex.org/F4320334629“,”“funder_display_name”:“生物技术和生物科学研究委员会”,“award_id”:“BB/T019670/1”}],“数据集”:[],“版本”:[[],“referenced_works_count”:65,“referrenced_works”:[”https://openalex.org/W1055665093","https://openalex.org/W1934094702","https://openalex.org/W1969096316","https://openalex.org/W1970357458","https://openalex.org/W1981849943","https://openalex.org/W2028554313","https://openalex.org/W2033308373","https://openalex.org/W2069860553","https://openalex.org/W2070050178","https://openalex.org/W2076688076","https://openalex.org/W2080752012","https://openalex.org/W2082471489","https://openalex.org/W2097259163","https://openalex.org/W2106876831","https://openalex.org/W2108503001","https://openalex.org/W2108516575","https://openalex.org/W2122637648","https://openalex.org/W2128502368","https://openalex.org/W2131856634","https://openalex.org/W2149441684","https://openalex.org/W2203664297","https://openalex.org/W2302003756","https://openalex.org/W2329674354","https://openalex.org/W2387888406","https://openalex.org/W2519691041","https://openalex.org/W2617865703","https://openalex.org/W2749613778","https://openalex.org/W2791658662","https://openalex.org/W2795924063","https://openalex.org/W2795989238","https://openalex.org/W2800353910","https://openalex.org/W2800750902","https://openalex.org/W2889646458","https://openalex.org/W2896740594","https://openalex.org/W2901481287","https://openalex.org/W2921968856","https://openalex.org/W2944545583","https://openalex.org/W2947864425","https://openalex.org/W2972935773","https://openalex.org/W2973108736","https://openalex.org/W2978644288","https://openalex.org/W2982521190","https://openalex.org/W2986748866","https://openalex.org/W2995155411","https://openalex.org/W3007699118","https://openalex.org/W3083834771","https://openalex.org/W3085081106","https://openalex.org/W3093282387","https://openalex.org/W3128646645","https://openalex.org/W3128756153","https://openalex.org/W3153131031","https://openalex.org/W3164360033","https://openalex.org/W3190031729","https://openalex.org/W3208691473","https://openalex.org/W3217192868","https://openalex.org/W4212764561","https://openalex.org/W4212836913","https://openalex.org/W4283034207","https://openalex.org/W4296621542","https://openalex.org/W4297900373","https://openalex.org/W4308834893","https://openalex.org/W4313279513","https://openalex.org/W4327704765","https://openalex.org/W4360821282","https://openalex.org/W4365143829“],”related_works“:[”https://openalex.org/W96119380","https://openalex.org/W4298030740","https://openalex.org/W4246773350","https://openalex.org/W3023706879","https://openalex.org/W2108949684","https://openalex.org/W2012655824","https://openalex.org/W1965976436","https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W112583468“],”abstract_inverted_index“:{”The“:[0169214],”cancer“:[1,18],”biomarker“:[2,96210],”field“:[3],”has“:[4,47218],“been”:[5,48219],”an“:[6,90],”object“:[7],”of“:[8,44,57,79116172196],”彻底“:[9],“调查”:[10],”in“:[11,50128141222],”The“],“最后”:[13],“几十年”:[14],“尽管”:[15],“这个”:[16],“结直肠”:[17],“(CRC)”:[19],“异质性”:[20],“制造”:[21],“它”:[22],“具有挑战性”:[23],“到”:[24,35,65,75,87112204],“识别”:[25],“和”:[26,37,85110123153163212],“验证”:[27],“有效”:[28],“预后”:[29170],“生物标志物”:[30158],“用于”:[31,811146209],“患者”:[32],“分类”:[331 48],“根据”:[34],“结果”:[36],“治疗“:[38],”回应。“:[39],”虽然“:[40],”a“:[41,93114143188206],”大量“:[42],”数量“:[43],”蛋白质组学“:[45,68101199],”数据“:[46,52133217],”存放“:[49],”公共“:[51,67100180198224],”存储库“:[53],”此“:[54132190],”丰富“:[55],”来源“:[56],”信息“:[58],”是“:[59],”巨大“:[60],“使用不足。“:[61],”这里,“:[62],”我们“:[63138],”尝试“:[64],”重用“:[66],”数据集“:[69102200],”有“:[70134166],”两个“:[71],”主要“:[72],”目标:“:[73],”i)“:[74],”生成“:[76],”假设“:[77],”(检测“:[78],”生物标志物“:[80],”他们的“:[82183],”后/下游“:[83],“验证”,“:[84],”(ii)“:[86],”验证“:[88],”使用“:[89178],”正交“:[91],”方法“:[92],”先前“:[94],”描述“:[95],”面板。“:[97],”Twelve“:[98],”CRC“:[99147167],”(主要是“:[103],”from“:[104120],”PRIDE“:[106],”database)“:[107],”were“:[108126],”re-analysed“:[109],”integrated“:[111],”create“:[C13205],”landscape“:[115],”protein“[1171525],”expression“。“:[118],”样本“:[119],”两者“:[121],”固体“:[122],”液体“:[124],”活检“:[125],”包括“:[127],”再分析。“:[130],”整合“:[131],”生存“:[135],”注释“:[136],”数据“:[137],”have“:[139],”validated“:[140],”silico“:[142],”sex-gene“:[144],”签名“:[145],”at“:[149],”level“,”:[152],“identified”:[154],“five”:[155],“new”:[156],“血检”:[157],“(CD14,”:%159],”PP IA,“:[160],”MRC2“:[161],”PRDX1“:[162],”TXNDC5)“:[164],”关联“:[165],”预后。“:[168],”值“:[171195],”这些“:[173],”血液衍生“:[174],”蛋白质“:[175],”是“:[176],”已确认“:[177],”附加“:[179],”数据集“:[181],”支持“:[182],”潜在“:[184],”临床“:[185],”价值。“:[186],“As”:[187],“结论”:[189],“概念证明”:[191],“研究”:[192],“论证”:[193],“再利用”:[197],“As”:[201],“基础”:[203],“有用”:[207],“资源”:[208225],“发现”:[211],“验证”。“:[213],”表达式“:[216],”生成“:[220],”可用“:[221],”表达“:[226],”图集。“:[227]},”cited_by_api_url“:”https://api.openalex.org/works?filter=cites:W4391094674“,”counts_by_year“:[{”年份“:2024,”cited_by_count“:3},{”年“:2023,”cited_by_count”:1}],”更新日期“:”2024-08-10T17:09:33.982564“,”创建日期“:“2024-01-23”}