{“id”:“https://openalex.org/W2996558805“,”doi“:”https://doi.org/10.1186/s12859-019-3253-z“,”title“:“蛋白质组学中的挑战:分析方法与DREAM蛋白质组学子挑战案例研究的比较”,”display_name“:“蛋白组学的挑战:与DREAM-蛋白质组学亚挑战案例研究中的分析方法比较”,“publication_year”:2019,“publitation_date”:“2019-12-01”,“ids”:{“openalex“:”https://openalex.org/W2996558805“,”doi“:”https://doi.org/10.1186/s12859-019-3253-z“,”mag“:”2996558805“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/31861998“,”pmcid“:”https://www.ncbi.nlm.nih.gov/pmc/articles/6923881“},”language“:”en“,”primary_location“:{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1186/s12859-019-3253-z,“pdf_url”:https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3253-z,“源”:{“id”:https://openalex.org/S19032547“,”display_name“:”BMC生物信息学“,”issn_l“:”1471-2105“,”isn“:[”1471-2115“],”is_oa“:true,”is_ in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310320256“,”“host_organization_name”:“BioMed Central”,“host_organization_lineage”:[“https://openalex.org/P431031965","https://openalex.org/P4310320256“],”host_organization_lineage_names“:[”Springer Nature“,”BioMed Central“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”type“:”article“,”type_crossref“:“journal-article”,”indexed_in“:[”crossref“,”publimed“],”open_access“:{”is_oa“:true,”oa_status“:”gold“,”oa_url“:”https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3253-z“,”any_repository_has_fulltext“:true},”authorships“:[{”author_position“:”第一“,”作者“:{”id“:”https://openalex.org/A5048150961“,”display_name“:”Tara Eicher“,”orcid“:”https://orcid.org/0000-0003-1809-4458},“机构”:[{“id”:https://openalex.org/I52357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Tara Eicher“,”raw_affiliation_strings“:[“俄亥俄州立大学计算机科学与工程系,俄亥俄州哥伦布,43210,美国”],”affiliations“:[{”raw_affiliation_string“:”俄亥俄州立大学计算机科学与工程系,俄亥俄州哥伦布,43210,USA“,”institution_ids“:[”https://openalex.org/I52357470“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5025824983“,”display_name“:”Andrew Patt“,”orcid“:null},”institutions“:[{”id“:”https://openalex.org/I52357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Andrew Patt“,”raw _affiliation_strings“:[“俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国”],”affiliations“:”俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国“,“institution_ids”:[“https://openalex.org/I52357470“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5064582385“,”display_name“:”Esko A.Kautto“,”orcid“:”https://orcid.org/0000-0001-8675-8506},“机构”:[{“id”:https://openalex.org/I523357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Esko Kautto“,”raw _ afiliation_strings“:[“俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国”],”affiliations“:[{”raw _affiliation_string“:”俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国“,“institution_ids”:[“https://openalex.org/I52357470“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5002832419“,”display_name“:”Raghu Machiraju“,”orcid“:”https://orcid.org/0000-0002-8101-8119},“机构”:[{“id”:https://openalex.org/I52357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Raghu Machiraju“,”raw _ afiliation_strings“:[“俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,USA”],”affiliations“:[{”raw_ afiliation _string“:”俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国“,“institution_ids”:[“https://openalex.org/I52357470“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5051353435“,”display_name“:”Ewy A.Math\u00e9“,”orcid“:”https://orcid.org/0000-0003-4491-8107},“机构”:[{“id”:https://openalex.org/I52357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Ewy Math\u00e9“,”raw _ afiliation_strings“:[“俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,USA”],”affiliations“:[{”raw_ afiliation _string“:”俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国“,“institution_ids”:[“https://openalex.org/I52357470“]}]},{”author_position“:”last“,”author“:{”id“:”https://openalex.org/A5086664284“,”display_name“:”Yan Zhang“,”orcid“:”https://orcid.org/0000-0002-9215-3842},“机构”:[{“id”:https://openalex.org/I52357470“,”display_name“:”俄亥俄州立大学“,”ror“:”https://ror.org/00rs6vg23“,”country_code“:”US“,”type“:“教育”,”世系“:[”https://openalex.org/I52357470“]}],”国家“:[”美国“],”is_corresponding“:false,”raw_author_name“:”Yan Zhang“,”raw _affiliation_strings“:[“俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国”],”affiliations“:”俄亥俄州立大学医学院生物医学信息学系,俄亥俄州哥伦布,43210,美国“,“institution_ids”:[“https://openalex.org/I52357470“]}]}],”countries_distinct_count“:1,”institutions_disting_count”:1,“corresponding_author_ids”:[],”correspounding_institution_ids“:[]、”apc_list“:{“value”:1690,”currency“:”GBP“,”value_usd“:2072,”provenance“:”doaj“},”apc_payed“:{”value“:1690 aj“},”fwci“:1.071,”has_fulltext“:true,”fulltext_origin“:”pdf”,“cited_by_count”:11,“cited_by_percentle_year”:{“min”:88,“max”:89},“biblio”:{“volume”:“20”,“issue”:“S24”,“first_page”:null,“last_page”:null},“is_retracted”:false,“is_paratext”:false,“primary_topic”:{“id”:“https://openalex.org/T10519“,”“display_name”:“蛋白质质谱技术”,“score”:0.9998,“subfield”:{“id”:“https://openalex.org/subfields/1607“,”display_name“:”光谱学“},”字段“:{”id“:”https://openalex.org/fields/16“,”display_name“:”Chemistry“},”domain“:{”id“:”https://openalex.org/domains/3“,”display_name“:”物理科学“}},”主题“:[{”id“:”https://openalex.org/T10519“,”“display_name”:“蛋白质质谱技术”,“score”:0.9998,“subfield”:{“id”:“https://openalex.org/subfields/1607“,”display_name“:”光谱学“},”字段“:{”id“:”https://openalex.org/fields/16“,”display_name“:”Chemistry“},”domain“:{”id“:”https://openalex.org/domains/3“,”display_name“:”物理科学“}},{”id“:”https://openalex.org/T10836“,”“display_name”:“代谢组学研究进展”,“score”:0.9986,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T10885“,”“display_name”:“微阵列数据分析和基因表达谱分析”,“score”:0.9945,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}}],”keywords“:[{”id“:”https://openalex.org/keywords/proteomics网站“,”display_name“:”蛋白质组学“,”score“:0.598563},{”id“:”https://openalex.org/关键词/磷酸蛋白质组学“,”display_name“:”磷蛋白组学“,”score“:0.527984},{”id“:”https://openalex.org/keywords/protein-identification网站“,”display_name“:”蛋白质鉴定“,”score“:0.521723}],”concepts“:[{”id“:”https://openalex.org/C145741570,“wikidata”:https://www.wikidata.org/wiki/Q7251534“,”display_name“:”蛋白质组学“,”level“:5,”score“:0.9808862},{”id“:”https://openalex.org/C70721500,“wikidata”:https://www.wikidata.org/wiki/Q177005“,”display_name“:”计算生物学“,”level“:1,”score“:0.62642956},{”id“:”https://openalex.org/C4611723,“wikidata”:https://www.wikidata.org/wiki/Q471857“,”display_name“:”蛋白质组学“,”level“:3,”score“:0.6263251},{”id“:”https://openalex.org/C86803240,“wikidata”:https://www.wikidata.org/wiki/Q420“,”display_name“:”生物学“,”等级“:0,”分数“:0.6178865},{”id“:”https://openalex.org/C104397665,“wikidata”:https://www.wikidata.org/wiki/Q860947“,”display_name“:”蛋白质组“,”level“:2,”score“:0.5723358},{”id“:”https://openalex.org/C95371953,“wikidata”:https://www.wikidata.org/wiki/Q591745“,”“display_name”“:”DNA微阵列“,”级别“:4,”分数“:0.45846567},{”id“:”https://openalex.org/C189206191,“wikidata”:https://www.wikidata.org/wiki/Q222046“,”display_name“:”Genomics“,”level“:4,”score“:0.40633643},{”id“:”https://openalex.org/C60644358,“wikidata”:https://www.wikidata.org/wiki/Q128570“,”display_name“:”生物信息学“,”level“:1,”score“:0.36170796},{”id“:”https://openalex.org/C104317684,“wikidata”:https://www.wikidata.org/wiki/Q7187“,”display_name“:”Gene“,”level“:2,”score“:0.293998},{”id“:”https://openalex.org/C150194340,“wikidata”:https://www.wikidata.org/wiki/Q26972“,”display_name“:”基因表达式“,”级别“:3,”分数“:0.22469941},{”id“:”https://openalex.org/C141231307,“wikidata”:https://www.wikidata.org/wiki/Q7020“,”display_name“:”基因组“,”level“:3,”score“:0.21647042},{”id“:”https://openalex.org/C54355233,“wikidata”:https://www.wikidata.org/wiki/Q7162“,”“display_name”“:”“Genetics”“,”level“:1,”score“:0.20070437}],”mesh“:[{”descriptor_ui“:”D000071696“,”descriptor _name“:”蛋白质组学“,”限定符_ui:“”,“限定符_name”:null,”“is_major_topic”“:true},{”描述符_ui{“描述符_ui”:“D005786”,“描述符名称“:”基因表达调控“,”限定符_ui“:”“,”限制符名称“:null,”is_major_topic“:false},{”描述符名称“:”D006801“,”描述符名称”:“人类”,”限定词_ui”:“”,“限定符名称”:null、“is_mayor_topical”:false},}”描述符名“:”蛋白质组“,”qualifier_ui{“descriptor_ui”:“D020543”,“descriptor_name”:“Proteome”,“qualifier_ui”:“Q000032”,“qualifier_name”:“analysis”,“is_major_topic”:false},{“descriptor_ui”:“D012333”,“descriptor_name”:“RNA,信使”,“qualifier_ui”:“Q000235”,“qualifier_name”:“genetics”,“is_major_topic”:false},{“descriptor_ui”:“D012333”,“descriptor_name”:“RNA,信使”,“qualifier_name”ui“:”“,”限定符名称“:null,”is_major_topic“:false},{”描述符用户界面“:”D059467“,”描述符名称“:”抄本“,”qualifier_ui“:”“,”qualifier_name“:null,”is _major _topic”:false}],“locations_count”:4,“location”:[{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1186/s12859-019-3253-z,“pdf_url”:https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3253-z,“源”:{“id”:https://openalex.org/S19032547“,”display_name“:”BMC生物信息学“,”issn_l“:”1471-2105“,”isn“:[”1471-2115“],”is_oa“:true,”is_ in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310320256“,”host_organization_name“:”生物医学中心“,”host_organization_lineage“:[”https://openalex.org/P431031965","https://openalex.org/P4310320256“],”host_organization_lineage_names“:[”Springer Nature“,”BioMed Central“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},{”is_oa“:true,”landing_page_url“:”https://europepmc.org/articles/pmc6923881,“pdf_url”:https://europepmc.org/articles/pmc6923881?pdf=render,“源”:{“id”:https://openalex.org/S4306400806“,”display_name“:”Europe PMC(PubMed Central)“,”issn_l“:null,”issn“:null,”is_oa“:true,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1303153112“,”“host_organization_name”:“欧洲生物信息学研究所”,“host_organization_lineage”:[“https://openalex.org/I1303153112“],”host_organization_lineage_names“:[”欧洲生物信息学研究所“],“type”:“repository”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},{”is_oa“:true,”landing_page_url“:”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923881“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S2764455111“,”display_name“:”PubMed Central“,”issn_l“:null,”issn“:null,”is_oa“:true,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:“publishedVersion”,“is_accepted”:true,“is_published”:true},{“is_oa”:false,“landing_page_url”:“https://pubmed.ncbi.nlm.nih.gov/31861998“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”美国国立卫生研究院“],”type“:”repository“},”license“:null,”license_id“:null,”version“:null,”is_accepted“:false,”is_published“:false}],”best_oa_location“:{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1186/s12859-019-3253-z,“pdf_url”:https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3253-z,“源”:{“id”:https://openalex.org/S19032547“,”display_name“:”BMC生物信息学“,”issn_l“:”1471-2105“,”isn“:[”1471-2115“],”is_oa“:true,”is_ in_doaj“:true,”is_core“:true,”host_organization“:”https://openalex.org/P4310320256“,”“host_organization_name”:“BioMed Central”,“host_organization_lineage”:[“https://openalex.org/P431031965","https://openalex.org/P4310320256“],”host_organization_lineage_names“:[”Springer Nature“,”BioMed Central“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”sustainable_development_goals“:[{”id“:”https://metadata.un.org/sdg/15“,”display_name“:”陆上生活“,”score“:0.57}],”grants“:[],”datasets“:[”https://openalex.org/W4394548402“],”版本“:[],”referenced_works_count“:28,”referrenced_works“:[”https://openalex.org/W1592076897","https://openalex.org/W1970298630","https://openalex.org/W1993404814","https://openalex.org/W2026433130","https://openalex.org/W2041373569","https://openalex.org/W2046253393网址","https://openalex.org/W2062258948","https://openalex.org/W2066622134","https://openalex.org/W2070632438","https://openalex.org/W2091374137","https://openalex.org/W2097343780","https://openalex.org/W2102796372","https://openalex.org/W2107363136","https://openalex.org/W2117625122","https://openalex.org/W2120016245","https://openalex.org/W2127919322","https://openalex.org/W2168361771","https://openalex.org/W2168442313","https://openalex.org/W2340761255","https://openalex.org/W2428070046","https://openalex.org/W2464880876","https://openalex.org/W2525409889","https://openalex.org/W2621121417","https://openalex.org/W2810172011","https://openalex.org/W2990138404","https://openalex.org/W4211007335","https://openalex.org/W4297710664","https://openalex.org/W4297947426“],”related_works“:[”https://openalex.org/W4390205769","https://openalex.org/W3022402204","https://openalex.org/W2391458050","https://openalex.org/W2347437365","https://openalex.org/W2146188580","https://openalex.org/W2124137418","https://openalex.org/W2106414650","https://openalex.org/W2086860678","https://openalex.org/W1999412725","https://openalex.org/W1982829397“],”ngrams_url“:”https://api.openalex.org/works/W2996558805/ngrams网站“,”abstract_inverted_index“:{”Proteomic“:[0],”measurements“:[1],”which“:[2],”closely“:[3],”reflect“:[4],”表型“:[5],”provide“:[6],”insideration“:[7],”into“:[8],”gene“:[9,28],”expression“:[10],”regulations“:[11],”and“:[12,23,44,68,83102119148],”mechanism“:[13],”underlying“:[14],”alternated“:[15],“表型。”:[16],“此外,”:[17],“集成“:[18],”of“:[19,75],”data“:[20,36,77],”on“:[21],”proteome“:[22],”transcriptome“:[24],”levels“:[25110141],”can“:[26106],”validate“:[27],”signatures“:[209],”associated“:[30],”with“:[3]111],”a“:[32],”表型。“:[33],”“然而,”:[34121],“蛋白质组”:[35,59,76],“是”:[37,46],“不是”:[38],“作为”:[39,41],“丰富”:[40],“基因组”:[42,51],“数据”:[43],“它”:[45],“因此”:[47],“有益”:[48],“到”:[49,53132],“使用”:[50],“特征”:[52],“预测”:[54107],“蛋白”:[55108140],“丰度”:[56],“何时”:[57],“匹配”:[58],“样本”:[60,64],“或”:[61],“测量值“:[62],”在“:[63]内”,“是”:[65],“缺乏。我们“:[66],“评估”:[67],“比较”:[69],“四”:[70],“数据驱动”:[71],“模型”:[72],“用于”:[73138],“预测”:[74],“来自”:[78142],“mRNA”:[79],“测量”:[80],“in”:[81151],“乳腺”:[82],“卵巢”:[84],“癌症”:[85],“使用”:[86],“the”:[87122],“2017”:[88],“梦想”:[89],“蛋白质组学”:[90],“挑战”:[91],“数据。“:[92],“我们的”:[93],“结果”:[94],“显示”:[95],“那”:[96],“贝叶斯”:[97],“网络”:[98],“随机”:[99],“森林”:[100],“LASSO”:[101],“模糊”:[103],“逻辑”:[104],“方法”:[105137],“丰度”:[109],“中值”:[112],“地面”:[113],“真实预测”:[114],“相关性”:[114]115],“值”:[116],“介于”:[11129],“0.2”:[118],“0.5”:[120],“最多”:[123],“准确”:[124],“预测”:[125],“蛋白质”:[126],“差异”:[127],“相当大”:[128],“方法。In”:[130],“加法”:[131],“基准”:[133],“前述”:[134],“机器”:[135],“学习”:[136],“预计”:[139],“转录本”:[143],“水平”:[144],“我们”:[145],“讨论”:[146],“挑战”:[147],“潜在”:[149],“解决方案”:[150],“最新技术”:[152],“蛋白质组学”:[153],“分析”:[154]},“引用by_api_url”:“https://api.openalex.org/works?filter=cites:W2996558805“,”counts_by_year“:[{“年”:2024,”cited_by_count“:1},{“年份”:2023,”ciped_by_cunt“:1},”{“年度”:2022,“cited_by_count”:3},“年份”:2021,”cited_by_count“,”创建日期“:”2019-12-26“}