{“id”:“https://openalex.org/W2163034016“,”doi“:”https://doi.org/10.1093/database/bar017“,”title“:”hERGAPDbase:记录化合物的hERG通道抑制电位和APD延长活性的数据库“,”display_name“:”h ERGAPDbase:记录化合物的hERG通道阻抑电位和APD-延长活性的数据“,”publication_year“:2011,”publitation_date“:”2011-05-17“,”ids“:{”openalex“:”https://openalex.org/W2163034016“,”doi“:”https://doi.org/10.1093/database/bar017“,”mag“:”2163034016“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/15856548“,”pmcid“:”https://www.ncbi.nlm.nih.gov/pmc/articles/3096323“},”language“:”en“,”primary_location“:{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1093/database/bar017,“pdf_url”:https://academy.oup.com/database/article-pdf/doi/10.1093/database/bar017/1259460/bar017.pdf,“源”:{“id”:https://openalex.org/S4210201630“,”display_name“:”Database“,”issn_l“:”1758-0463“,”issn“:[”1758-0463“],”is_oa“:true,”is_in_doaj“:true,”host_organization“:”https://openalex.org/P4310311647“,”“host_organization_name”:“牛津大学”,“host_ordanization_lineage”:[“https://openalex.org/P4310311647“],”host_organization_lineage_names“:[”牛津大学“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”type“:”article“,”type_crossref“:“journal-article”,”indexed_in“:[”crossref“,”publimed“],”open_access“:{”is_oa“:true,”oa_status“:”gold“,”oa_url“:”https://academy.oup.com/database/article-pdf/doi/10.1093/database/bar017/1259460/bar017.pdf“,”any_repository_has_fulltext“:true},”authorships“:[{”author_position“:”第一“,”作者“:{”id“:”https://openalex.org/A5065531808“,”display_name“:”Haretugu Hishigaki“,”orcid“:null},”institutions“:[{”id“:”https://openalex.org/I4210143148“,”display_name“:”大冢制药(西班牙)“,”ror“:”https://ror.org/04tqd7s80“,”country_code“:”ES“,”type“:“company”,”lineage“:[”https://openalex.org/I4210143148“]},{”id“:”https://openalex.org/I135598925“,”display_name“:”九州大学“,”ror“:”https://ror.org/00p4k0j84“,”country_code“:”JP“,”type“:“教育”,”世系“:[”https://openalex.org/I135598925“]}],”国家“:[”ES“,”JP“],”is_corresponding“:false,”raw_author_name“:”H.Hishigaki“,”raw _affiliation_strings“:[“463-10 Kagasuno Kawauchi-cho,Tokushima 771-0192,Japan”,“九州大学农业学院遗传资源技术系,6-10-1 Hakozaki,Higashi ku,Fukuka 812-8581和2生物医药创新研究所,Otsuka Pharmaceutical Co.Ltd.“]},{“author_position”:“last”,“author”:{“id”:“https://openalex.org/A5067172907“,”display_name“:”Satoru Kuhara“,”orcid“:null},”institutions“:[{”id“:”https://openalex.org/I135598925“,”display_name“:”九州大学“,”ror“:”https://ror.org/00p4k0j84“,”country_code“:”JP“,”type“:“教育”,”世系“:[”https://openalex.org/I135598925“]},{”id“:”https://openalex.org/I4210143148“,”display_name“:”大冢制药(西班牙)“,”ror“:”https://ror.org/04tqd7s80“,”country_code“:”ES“,”type“:“company”,”lineage“:[”https://openalex.org/I4210143148“]}],”国家“:[”ES“,”JP“],”is_corresponding“:true,”raw_author_name“:”S.Kuhara“,”raw _affiliation_strings“:[“463-10 Kagasuno Kawauchi-cho,Tokushima 771-0192,Japan”,“九州大学农业学院遗传资源技术系,地址:6-10-1 Hakozaki,Higashi-ku,Fukuoka 812-8581和2大冢制药有限公司生物医学创新研究所“]}],“countries_distict_count”:2,“institutions_disticent_count”:2中,“corresponding_author_ids”:[“https://openalex.org/A5067172907“],”对应的机构ID“:[”https://openalex.org/I135598925","https://openalex.org/I4210143148“],”apc_list“:{”value“:1415,”currency“:”GBP“,”value_usd“:1735,”出处“:”doaj“},”apc_payed“:{”value“:1415,”currency“:”GBP“,”value_usd“:1735,”出处“:”doaj“},”has_fulltext“:true,”fulltext_origin“:”pdf“,”cited_by_count“:11,”cited_by_percentle_year“:{”min“:87,”max“:88},”biblio“:{”volume“:”2011“,”issue“:”0“,”first_page“:”bar017“,”last_page“:”bar017“},”is_retracted“:false,”is_paratext“:fase,”primary_topic“:{”id“:”https://openalex.org/T10217“,”“display_name”:“心律失常的分子机制”,“score”:0.9999,“subfield”:{“id”:“https://openalex.org/subfields/2705“,”display_name“:”心脏病学和心血管医学“},”字段“:{”id“:”https://openalex.org/fields/27“,”display_name“:”Medicine“},”domain“:{”id“:”https://openalex.org/domains/4“,”display_name“:”Health Sciences“}},”topics“:[{”id“:”https://openalex.org/T10217“,”“display_name”:“心律失常的分子机制”,“score”:0.9999,“subfield”:{“id”:“https://openalex.org/subfields/2705“,”display_name“:”心脏病学和心血管医学“},”字段“:{”id“:”https://openalex.org/fields/27“,”display_name“:”Medicine“},”domain“:{”id“:”https://openalex.org/domains/4“,”“display_name”:“健康科学”}},{”id“:”https://openalex.org/T10493“,”“display_name”:“离子通道调控的分子机制”,“score”:0.9987,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T11178“,”display_name“:”G蛋白偶联受体的结构和功能“,”score“:0.9825,”subfield“:{”id“:”https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}}],”关键词“:[{”id“:”https://openalex.org/keywords/药物发现“,”display_name“:”药物发现“,”score“:0.439618}],”概念“:[{”id“:”https://openalex.org/C2779362680,“wikidata”:https://www.wikidata.org/wiki/Q905000“,”display_name“:”hERG“,”level“:3,”score“:0.9713885},{”id“:”https://openalex.org/C2777672339,“wikidata”:https://www.wikidata.org/wiki/Q7249641“,”display_name“:”延长“,”级别“:2,”分数“:0.82784367},{”id“:”https://openalex.org/C118441451,“wikidata”:https://www.wikidata.org/wiki/Q12074763“,”display_name“:”QT间期“,”level“:2,”score“:0.76924247},{”id“:”https://openalex.org/C278077758,“wikidata”:https://www.wikidata.org/wiki/Q418050“,”display_name“:”Sertindole“,”level“:4,”score“:0.71768343},{”id“:”https://openalex.org/C98274493,“wikidata”:https://www.wikidata.org/wiki/Q128406“,”display_name“:”药理学“,”level“:1,”score“:0.65025234},{”id“:”https://openalex.org/C2776129107,“wikidata”:https://www.wikidata.org/wiki/Q423437“,”display_name“:”阿斯替咪唑“,”level“:2,”score“:0.60939044},{”id“:”https://openalex.org/C71924100,“wikidata”:https://www.wikidata.org/wiki/Q11190(网址:https://www.wikidata.org/wiki/Q11190)“,”display_name“:”Medicine“,”level“:0,”score“:0.5137676},{”id“:”https://openalex.org/C2779703243,“wikidata”:https://www.wikidata.org/wiki/Q653924“,”display_name“:”长QT综合征“,”level“:3,”score“:0.49748138},{”id“:”https://openalex.org/C2780035454,“wikidata”:https://www.wikidata.org/wiki/Q8386“,”display_name“:”Drug“,”level“:2,”score“:0.48673323},{”id“:”https://openalex.org/C2776190711,“wikidata”:https://www.wikidata.org/wiki/Q7398663“,”display_name“:”安全药理学“,”level“:3,”score“:0.4866627},{”id“:”https://openalex.org/C42219234,“wikidata”:https://www.wikidata.org/wiki/Q131130“,”display_name“:”麻醉“,”level“:1,”score“:0.23409685},{”id“:”https://openalex.org/C83743174,“wikidata”:https://www.wikidata.org/wiki/Q423778“,”display_name“:”钾通道“,”level“:2,”score“:0.20991427},{”id“:”https://openalex.org/C12632202,“wikidata”:https://www.wikidata.org/wiki/Q11180“,”display_name“:”内科“,”level“:1,”score“:0.18600047},{”id“:”https://openalex.org/C2780948584,“wikidata”:https://www.wikidata.org/wiki/Q251347“,”display_name“:”氟哌啶醇“,”level“:3,”score“:0.0},{”id“:”https://openalex.org/C513476851,“wikidata”:https://www.wikidata.org/wiki/Q170304“,”display_name“:”Dopamine“,”level“:2,”score“:0.0}],”mesh“:[{”descriptor_ui“:”D016208“,”描述符名称“:”数据库,事实“,”qualifier_ui”:“”,“限定符名称”:null,“is_major_topic”:true},{”描述符名称“:true},{”descriptor_ui“:”D051638“,”descriptor_name“:”Ether-A-Go-Go钾通道“,”qualifier_ui”:“Q000037”,“qualifier _name”:“拮抗剂和抑制剂”,“is_major_topic”:true},{“descriptor_ ui”:“D006329”,“descriptor _name”:“心脏传导系统”,“qualifier _ui(限定符_ui):“Q00187”,“限定符_name”(限定符_名称):“药物效应”,“is _major _topic(is_mayoc)”:true},“描述符_ui描述符名称“:”动作电位“,”限定符_ui“:”Q000187“,”qualifier_name“:”药物效应“,”is_major_topic“:false},{“描述符_ui”:“D000200”,“描述符名称”:“动作电位”,“限定符_ui”:“Q000502”,“qualifier _name”:“生理学”,“is_mayor_toptic”:false},}“描述符_ ui”“:”D000200“,”描述符名称“:”动作电位限定符名称“:null,”is_major_topic“:false},”描述符名称“:”D000818“,”描述符姓名“:”动物“,”限定符_ui“:”“,”标识符名称“:null,”is _major _topic”:false},“描述符名称”:“D057225”,“描述符姓名”:“数据挖掘”,”限定词_ui药物评估,临床前”,“qualifier_ui”:“”,“qualifier_name”:null,“is_major_topic”:false},{“descriptor_ui”:“D056736”,“descriptor_name”:“药物召回”,“qualifier_ui”:“”,“qualifier_name”:null,“is_major_topic”:false},{“descriptor_ui”:“D004562”,“descriptor_name”:“心电图”,“qualifier_ui”:“”,“qualifier_name”:null,“is_major_topic”:false},{“描述符_ui”:“D004562”,“描述符名称”:“心电图”,“限定符_ui“:”Q000187“,”限定符名称“:”药物效应“,”is_major_topic“:false},{”描述符名称“:“D051638”,“descriptor_name”:“Ether-A-Go-Go钾通道”,“qualifier_ui:“豚鼠”,“qualifier_ui”:“”,“qualifier_name”:null,“is_major_topic”:false},{“descriptor_ui“:”D057809“,”descriptor_name“:”HEK293 Cells“,”qualifier _ui:“”_主题“:false},{“描述符_ui”:“D006329”,“描述符名称”:“心脏传导系统”,“限定符_ui“:”,“修饰符名称”:null,“is_major_topic”:false},“描述符名”:“D 006801”,“说明符名称”,“人类”,“qualifier _ui:”,“”,“限定符名称”:null,“is_major_topic”:false},{“描述符_用户界面”:“D019739”,“描述符名称”:“骨骼肌心室”,“限定词_ui”:“”,“qualifier名称”:null,“is _major _主题”:false},}“描述符_ui“:”D014584“描述符名称“:”用户-计算机界面“,”限定词_ui“:”,“标识符名称”:null,“is _ major _topic 14981英寸,“描述符名称”:“Xenopus”,“限定符_ui”:“”,“限制符名称”:null,“is_major_topic”:false}],“位置_计数”:4,“位置”:[{“is_oa”:true,“landing_page_url”:“https://doi.org/10.1093/database/bar017,“pdf_url”:https://academy.oup.com/database/article-pdf/doi/10.1093/database/bar017/1259460/bar017.pdf,“源”:{“id”:https://openalex.org/S4210201630“,”display_name“:”Database“,”issn_l“:”1758-0463“,”isn“:[”1758-0663“],”is_oa“:true,”is-in_doaj“:true,”host_organization“:”https://openalex.org/P4310311647“,”“host_organization_name”:“牛津大学”,“host_ordanization_lineage”:[“https://openalex.org/P4310311647“],”host_organization_lineage_names“:[”牛津大学“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},{”is_oa“:true,”landing_page_url“:”https://europepmc.org/articles/pmc3096323,“pdf_url”:https://europepmc.org/articles/pmc3096323?pdf=render,“源”:{“id”:https://openalex.org/S4306400806“,”display_name“:”Europe PMC(PubMed Central)“,”issn_l“:null,”issn“:null,”is_oa“:true,”is_ in_doaj“:false,”host_organization“:”https://openalex.org/I1303153112“,”“host_organization_name”:“欧洲生物信息学研究所”,“host_organization_lineage”:[“https://openalex.org/I1303153112“],”host_organization_lineage_names“:[”欧洲生物信息学研究所“],“type”:“repository”},“license”:“cc-by-nc”,“licence_id”:“https://openalex.org/licenses/cc-by-nc“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},{”is_oa“:true,”landing_page_url“:”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096323“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S2764455111“,”display_name“:”PubMed Central“,”issn_l“:null,”issn“:null,”is_oa“:true,”is_ in_doaj“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:“publishedVersion”,“is_accepted”:true,“is_published”:true},{“is_oa”:false,“landing_page_url”:“https://pubmed.ncbi.nlm.nih.gov/21586548“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_in_doaj“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false}],“best_oa_location”:{“is_oa”:true,“landing_page_url”:“https://doi.org/10.1093/database/bar017,“pdf_url”:https://academic.oup.com/database/article-pdf/doi/10.1093/database/bar017/1259460/bar017.pdf,“源”:{“id”:https://openalex.org/S4210201630“,”display_name“:”Database“,”issn_l“:”1758-0463“,”isn“:[”1758-0663“],”is_oa“:true,”is-in_doaj“:true,”host_organization“:”https://openalex.org/P4310311647“,”“host_organization_name”:“牛津大学”,“host_ordanization_lineage”:[“https://openalex.org/P4310311647“],”host_organization_lineage_names“:[”牛津大学“],“type”:“journal”},“license”:“cc-by”,“licence_id”:“https://openalex.org/licenses/cc-by“,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”sustainable_development_goals“:[{”id“:”https://metadata.un.org/sdg/3“,”score“:0.78,”display_name“:”良好的健康和幸福“}],”grants“:[],”dataset“:[],”versions“:[],”referenced_works_count“:14,”referenced_works“:[”https://openalex.org/W2021775591","https://openalex.org/W2023083670","https://openalex.org/W2041097104","https://openalex.org/W2089589794","https://openalex.org/W2114326383","https://openalex.org/W2116581628","https://openalex.org/W2127553917","https://openalex.org/W2145957401","https://openalex.org/W2159153323","https://openalex.org/W2163867408","https://openalex.org/W2331484064","https://openalex.org/W2519246214","https://openalex.org/W3217612474","https://openalex.org/W4239678514“],”related_works“:[”https://openalex.org/W2763384548","https://openalex.org/W2581748859","https://openalex.org/W2163034016","https://openalex.org/W2122199994","https://openalex.org/W2113927644","https://openalex.org/W2088898515","https://openalex.org/W2070682505","https://openalex.org/W2040319666","https://openalex.org/W2023083670","https://openalex.org/W1508014482“],”ngrams_url“:”https://api.openalex.org/works/W2163034016/ngrams网站“,”“abstract_inverted_index”:{“Drug-induced”:[0],“QT”:[1,54,80],“interval”:[2,55,81],“extendation”:[3,82,98],“is”:[4,60107],“one”:[5],“of”:[6,14,52,68,78,87,99110124],“the”:[7,12,17,20,42,66,88100121],“most”:[8,75],“common”:[9,76],“reasons”:[10],“for”:[11],71149],“退出”:[13],“药物”:[15,69],“来自”:[16,41133],“市场”:[18],“进入”:[19],“过去”:[21],“十年”:[22],“在”:[23],“最少”:[24],“九”:[25],“药物”:[26],“即”:[27],“特非那定”:[28],“阿司咪唑”:[29],“格列帕沙星”:[30],“terodiline”:[31],“氟哌啶”:[32],“利多嗪”:[33],“塞丁多尔”:[34],“左旋甲氧基”:[35],“和”:[36120136151154],“西沙必利,”:[37],“have”:[38],“been”:[39,48],“removed”:[40],“market”:[43],“或“:[44],”他们的“:[45],”使用“:[46],”有“:[47],”严重“:[49],”限制“:[50],”因为“:[51],”药物诱导“:[53,79],”延长。“:[56],”因此,“:[57],”此“:[58],”违规“:[59],”a“:[61108139],”主要“:[62],”安全“:[63],”关注“:[64],”in“:[65,97],”case“:[67],”submitted“:[70],”监管“:[72],”批准。“:[73],“The”:[74],“mechanism”:[77],“may”:[83],“be”:[84],“drug related”:[85],“inhibition”:[86],“human”:[89],“ether-\u00e1-go-go-related”:[90],“gene”:[91],“(hERG)”:[92],“channel”:[93],“which”:[94],“surrently”:[95],“results”:[96],“cardial”:[101],“action”:[102],“潜在”:[103115],“持续时间”:[104],“(APD)。“:[105],”hERGAPDbase“:[106],”数据库“:[109],”电生理“:[11159],”实验“:[1112160],”数据“:[113128161],”记录“:[114],”h ERG“:[116],”通道“:[117],”抑制“:[118],”作用“:[119],”APD延长“:[122],”活性“:[123],”化学“:[125150163],”化合物。“:[126164],“全部”:[127],“条目”:[129],“是”:[130],“手动”:[131],“收集”:[132],“科学”:[134],“论文”:[135],“策展”:[137],“作者”:[138],“个人”。“:[140],”With“:[141],”hERGAPDbase“:[142],”we“:[143],”aim“:[144],”to“:[145158],”provide“:[146],”有用“:[147],”information“:[148],”pharmacolocal“:[152],”scientists“:[153],”enable“:[155],”easy“:[156],”access“:[157],”on“:[162],”Database“:[165],”URL:“:[166],”http://www.grt.kyushu-u.ac.jp/hergapdbase/。“:[167]},”cited_by_api_url“:”https://api.openalex.org/works?filter=cites:W2163034016“,”“counts_by_year”:[{“年份”:2024,”“cited_by_count”:1},{“年度”:2022,”“cited_by_cunt”:1',{(年份):2021,年份“:2013,”cited_by_count“:1},{“年份”:2012,”cited_by_count”:1}],“updated_date”:“2024-06-05T21:59:27893933“,”创建日期“:”2016-06-24“}