{“id”:“https://openalex.org/W2887519731“,”doi“:”https://doi.org/10.1021/acs.jcim.8b00146“,”title“:”Node-Weighted Amino Acid Network Strategy for Characterization and Identification of Protein Functional Recess“,”display_name“:”蛋白质功能残留物表征和识别的节点加权氨基酸网络策略“,”publication_year“:2018,”publiation_date“:”2018-08-14“,”ids“:{”openalex“:”https://openalex.org/W2887519731“,”doi“:”https://doi.org/10.1021/acs.jcim.8b00146“,”mag“:”2887519731“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/30107728“},”language“:”en“,”primary_location“:{”is_oa“:false,”landing_page_url“:”https://doi.org/10.1021/acs.jcim.8b00146“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S167262187“,”display_name“:”化学信息与建模杂志“,”issn_l“:”1549-9596“,”isn“:[”1549-95%“,”1549-960X“],”is_oa“:false,”is_in_doaj“:false,”is_core“:true,”host_organization“:”https://openalex.org/P431032006“,”“host_organization_name”:“美国化学学会”,“host_ordanization_lineage”:[“https://openalex.org/P431032006“],”host_organization_lineage_names“:[”American Chemical Society“],”type“:”journal“},”license“:null,”license_id“:null,”version“:null,”is_accepted“:false,”is_published“:false},”type“:”article“,”type_crossref“:”journal article“,”indexed_in“:[”crossref“,”pubmed“],”open_access“:{”is_oa“:false,”oa_status“:”closed“,”oa_url“:null,”any_repository_has_fulltext“:false},”作者身份“:[{”作者位置“:”第一个“,”作者“:{”id“:”https://openalex.org/A5002678361“,”display_name“:”Wenying Yan“,”orcid“:”https://orcid.org/0000-0001-5016-575X},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”Wenying Yan“,”raw _affiliation_strings“:[“苏州大学系统生物学中心,中国苏州215006”],”affiliations“:[{”raw _affiliation_string“:”苏州苏州大学系统生物中心,“institution_ids”:[“https://openalex.org/I3923682“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5061137912“,”display_name“:”Guang Hu“,”orcid“:”https://orcid.org/0000-0003-0437-4723},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”Guang Hu“,”raw _affiliation_strings“:[“中国苏州苏州大学系统生物学中心,215006”],“affiliations”:[{“raw_affilition_string”:“中国苏州大学系统生物中心,21500”,“institution_ids”:[“https://openalex.org/I3923682“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5045167053“,”display_name“:”梁忠杰“,”兽人“:”https://orcid.org/0000-0003-0763-5407},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”梁忠杰“,”raw _ afiliation_strings“:[“苏州大学系统生物学中心,中国苏州215006”],”affiliations“:[{”raw_ afiliation _string“:”苏州苏州大学系统生物中心,中国215006https://openalex.org/I3923682“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5078556234“,”display_name“:”周建红“,”兽人“:”https://orcid.org/0009-0001-6091-7318},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”周建宏“,”raw_affiation_strings“:[”苏州大学系统生物学中心,中国苏州215006“],”附属机构“:[{”raw_affiation_string“:”苏州大学系统生物学中心,中国苏州215006“,”institution_ids“:[”https://openalex.org/I3923682“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5049692788“,”display_name“:”Yang\uffd Yang“,”orcid“:”https://orcid.org/0000-0001-6441-0226},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]}],”countries“:[”CN“],”is_corresponding“:false,”raw_author_name“:”Yang Yang“,”raw _affiliation_strings“:【”苏州大学计算机科学与技术学院,苏州215006“】,”affiliations“:[{”raw _affiliation_string“:”苏州苏州大学计算机科技学院,苏州市215006”,“institution_ids”:[“https://openalex.org/I3923682“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5052198607“,”display_name“:”陈佳佳“,”兽人“:”https://orcid.org/0000-0003-1044-7079},“机构”:[{“id”:https://openalex.org/I308837“,”display_name“:”苏州科技大学“,”ror“:”https://ror.org/04en8wb91“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I308837“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”陈佳佳“,”raw _ afiliation_strings“:[“苏州理工大学化学、生物与材料工程学院,苏州215011”],”affiliations“:”苏州科技大学化学、生物与材料工程学院,中国苏州215011”,“机构ID”:[”https://openalex.org/I308837“]}]},{”author_position“:”last“,”author“:{”id“:”https://openalex.org/A5060766047“,”display_name“:”百荣神“,”兽人“:”https://orcid.org/0000-0003-2899-1531},“机构”:[{“id”:https://openalex.org/I3923682“,”display_name“:”苏州大学“,”ror“:”https://ror.org/05t8y2r12“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I3923682“]}],”countries“:[”CN“],”is_corresponding“:true,”raw_author_name“:”Bairong Shen“,”raw _affiliation_strings“:【”苏州大学系统生物学中心,苏州215006“】,”affiliations“:[{”raw _affiliation_string“:”苏州苏州苏州大学系统生物中心,“institution_ids”:[“https://openalex.org/I3923682“]}]}],”countries_disticont_count“:1,”institutions_disticent_count”:2,”corresponding_author_ids“:[”https://openalex.org/A5060766047“],”对应的机构ID“:[”https://openalex.org/I3923682“],”apc_list“:null,”apc _ paid“:nul,”fwci“:0.609,”has_fulltext“:true,”fulltext_origin“:”ngrams“,”cited_by_count“:22,”ciped_by_percentile_year“:{”min“:93,”max“:94},”biblio“:{-”volume“:58”,“issue”:“9”,“first_page”:“2024”,“last_page”:“2032”},“is_retracted”:false,“is_paratext”:false,“primary_topic”:{“id”:“https://openalex.org/T10044“,”display_name“:”蛋白质结构预测与分析“,”score“:0.9998,”subfield“:{”id“:”https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},”主题“:[{”id“:”https://openalex.org/T10044“,”display_name“:”蛋白质结构预测与分析“,”score“:0.9998,”subfield“:{”id“:”https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T12254“,”“display_name”:“蛋白质亚细胞定位预测”,“score”:0.9991,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T10211“,”“display_name”:“药物发现中的计算方法”,“score”:0.999,“subfield”:{“id”:“https://openalex.org/subfields/1703“,”display_name“:”计算理论与数学“},”字段“:{”id“:”https://openalex.org/fields/17“,”display_name“:”Computer Science“},”domain“:{”id“:”https://openalex.org/domains/3“,”display_name“:”物理科学“}}],”关键词“:[{”id“:”https://openalex.org/keywords/network-pharmacology网站“,”display_name“:”网络药理学“,”score“:0.519576},{”id“:”https://openalex.org/keywords/protein-interaction-networks网站“,”display_name“:”蛋白质相互作用网络“,”score“:0.510444}],”concepts“:[{”id“:”https://openalex.org/C116834253,“wikidata”:https://www.wikidata.org/wiki/Q2039217“,”display_name“:”Identification(biology)“,”level“:2,”score“:0.688667},{”id“:”https://openalex.org/C62611344,“wikidata”:https://www.wikidata.org/wiki/Q1062658“,”display_name“:”节点(物理)“,”级别“:2,”分数“:0.6089286},{”id“:”https://openalex.org/C2780841128,“wikidata”:https://www.wikidata.org/wiki/Q5073781“,”display_name“:”表征(材料科学)“,”level“:2,”score“:0.5731409},{”id“:”https://openalex.org/C70721500,“wikidata”:https://www.wikidata.org/wiki/Q177005“,”display_name“:”计算生物学“,”level“:1,”score“:0.49373588},{”id“:”https://openalex.org/C515207424,“wikidata”:https://www.wikidata.org/wiki/Q8066“,”display_name“:”氨基酸“,”level“:2,”score“:0.4365648},{”id“:”https://openalex.org/C185592680,“wikidata”:https://www.wikidata.org/wiki/Q2329“,”display_name“:”Chemistry“,”level“:0,”score“:0.39364678},{”id“:”https://openalex.org/C41008148,“wikidata”:https://www.wikidata.org/wiki/Q21198“,”display_name“:”计算机科学“,”level“:0,”score“:0.39019716},{”id“:”https://openalex.org/C55493867,“wikidata”:https://www.wikidata.org/wiki/Q7094“,”display_name“:”生物化学“,”level“:1,”score“:0.3257084},{”id“:”https://openalex.org/C86803240,“wikidata”:https://www.wikidata.org/wiki/Q420“,”display_name“:”生物学“,”等级“:0,”分数“:0.25384766},{”id“:”https://openalex.org/C171250308,“wikidata”:https://www.wikidata.org/wiki/Q11468“,”display_name“:”Nanotechnology“,”level“:1,”score“:0.107265115},{”id“:”https://openalex.org/C192562407,“wikidata”:https://www.wikidata.org/wiki/Q228736“,”display_name“:”材料科学“,”level“:0,”score“:0.10149631},{”id“:”https://openalex.org/C59822182,“wikidata”:https://www.wikidata.org/wiki/Q441“,”display_name“:”植物学“,”level“:1,”score“:0.09230152},{”id“:”https://openalex.org/C127413603,“wikidata”:https://www.wikidata.org/wiki/Q11023“,”display_name“:”Engineering“,”level“:0,”score“:0.09206194},{”id“:”https://openalex.org/C66938386,“wikidata”:https://www.wikidata.org/wiki/Q633538“,”display_name“:”Structural engineering“,”level“:1,”score“:0.0}],”mesh“:[{”descriptor_ui“:”D019295“,”descriptor_name“:”计算生物学“,”qualifier_ui“:”Q000379“,”qualifieer_name“:”methods“,”is_major_topic“:true},{”descriptor_ui“:”D030562“,”descriptor_name“:”数据库,蛋白质“,”qualifier_ui“:”“,”qualifier_name“:null,”is_major_topic“:true},{”descriptor_ui“:”D011506“,”descriptor_name“:”蛋白质“,”限定符_ui”:“Q000737”,“限定符_name”:“化学”,“is_major_topic”:真},{“descriptor_ ui”:“D000596”,“描述符_name”:“氨基酸”,“qualifier_ui):“Q000 737”“限定符_ui”:“”,“qualifier_name“:null,”is_major_topic“:false},{“描述符_用户界面”:“D019295”,“描述符_名称”:“计算生物学”,“限定符_ui”:“”,“qualifier _name”:null,“is_mayor_topical”:false},}“描述符_ui“:”D00006955“,”描述符_名称“:”机器学习“,”限定符_ui“:”“,”qualifier-name“:null,”is_ major_topic“:false{“descriptor_ui:”D011487“,”描述符名称“:”蛋白质构象“,”限定符_ui“:”“,”修饰符名称“:null,”is_major_topic“:false},{”描述符名称“:”D011506“,”描述符名称”:“蛋白质”,”限定词_ui”:“”,“限定符名称”:null、”is_marjor_top“:false}],“locations_count”:2,“location”:[{“is_oa”:false,“landing_page_url”:“https://doi.org/10.1021/acs.jcim.8b00146“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S167262187“,”display_name“:”化学信息与建模杂志“,”issn_l“:”1549-9596“,”isn“:[”1549-95%“,”1549-960X“],”is_oa“:false,”is_in_doaj“:false,”is_core“:true,”host_organization“:”https://openalex.org/P431032006“,”“host_organization_name”:“美国化学学会”,“host_ordanization_lineage”:[“https://openalex.org/P431032006“],”host_organization_lineage_names“:[”American Chemical Society“],“type”:“journal”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false},{“is_oa”:false,“landing_page_url”:“https://pubmed.ncbi.nlm.nih.gov/30107728“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false}],“best_oa_location”:nul,“sustainable_development_goals”:[{“score”:0.74,“id”:”https://metadata.un.org/sdg/7“,”display_name“:”负担得起的清洁能源“}],”grants“:[{”funder“:”https://openalex.org/F4320321001“,”“funder_display_name”:“国家自然科学基金”,“award_id”:“91530320”},{“funder”:“https://openalex.org/F4320321001“,”funder_display_name“:”国家自然科学基金“,”award_id“:”31400712“},{”funder“:”https://openalex.org/F4320321001“,”“funder_display_name”:“国家自然科学基金”,“award_id”:“61602332”},{“funder”:“https://openalex.org/F4320321001“,”“funder_display_name”:“国家自然科学基金”,“award_id”:“31600671”},{“funder”:“https://openalex.org/F4320321605“,”funder_display_name“:”江苏省政府“,”award_id“:”14KJB520035“}],”datasets“:[],”versions“:[],”referenced_works_count“:74,”referrenced_works“:[”https://openalex.org/W1819481941","https://openalex.org/W1967293793","https://openalex.org/W1971195826","https://openalex.org/W1972221499","https://openalex.org/W1981122373","https://openalex.org/W1982874561","https://openalex.org/W1986719264","https://openalex.org/W1986795645","https://openalex.org/W1987819535","https://openalex.org/W1989181256","https://openalex.org/W1990320360","https://openalex.org/W1990460499","https://openalex.org/W1991605720","https://openalex.org/W1996446367","https://openalex.org/W1998053010","https://openalex.org/W2000747101","https://openalex.org/W2008708467","https://openalex.org/W2014731953","https://openalex.org/W2025630031","https://openalex.org/W2031291897","https://openalex.org/W2038324414","https://openalex.org/W2048917743","https://openalex.org/W2073746700","https://openalex.org/W2075155374","https://openalex.org/W2077349723","https://openalex.org/W2092810439","https://openalex.org/W2097944242","https://openalex.org/W2098914939","https://openalex.org/W2105316179","https://openalex.org/W2114868131","https://openalex.org/W2122854841","https://openalex.org/W2124676068","https://openalex.org/W2125299915","https://openalex.org/W2128393152","https://openalex.org/W2130479394","https://openalex.org/W2130809031","https://openalex.org/W2132886170","https://openalex.org/W2133350649","https://openalex.org/W2136224545","https://openalex.org/W2137974866","https://openalex.org/W2140239055","https://openalex.org/W2140687507","https://openalex.org/W2141624700","https://openalex.org/W2141960720","https://openalex.org/W2142025713","https://openalex.org/W2143887102","https://openalex.org/W2144391203","https://openalex.org/W2145126338","https://openalex.org/W2147526198","https://openalex.org/W2150192011","https://openalex.org/W2154319440","https://openalex.org/W2157122545","https://openalex.org/W2157605186","https://openalex.org/W2157735020","https://openalex.org/W2159093475","https://openalex.org/W2160975112","https://openalex.org/W2168164063","https://openalex.org/W2170317338","https://openalex.org/W2175309784","https://openalex.org/W21771241999","https://openalex.org/W2288665025","https://openalex.org/W2290562923","https://openalex.org/W2325652290","https://openalex.org/W2345718491","https://openalex.org/W2395425574","https://openalex.org/W2519777545","https://openalex.org/W2523926726","https://openalex.org/W2533967599","https://openalex.org/W2609293186","https://openalex.org/W2777899362","https://openalex.org/W2777941847","https://openalex.org/W2792363117","https://openalex.org/W2795011345","https://openalex.org/W3098217834“],”related_works“:[”https://openalex.org/W4247143848","https://openalex.org/W330727063","https://openalex.org/W3107994849","https://openalex.org/W29442446","https://openalex.org/W2896904446","https://openalex.org/W2735573198","https://openalex.org/W2193237397","https://openalex.org/W2084679820","https://openalex.org/W2009883749","https://openalex.org/W1483407203“],”ngrams_url“:”https://api.openalex.org/works/W2887519731/ngrams网站“,”“abstract_inverted_index”:{“The”:[0,15135177],“study”:[1],“of”:[2,38,53,59,84110133],“functional”:[3186],“resuments”:[4139],“(FRs)”:[5],“is”:[6192],“essential”:[7],“for”:[8,25160166174195],“understanding”:[9],“protein”:[10],“functions”:[11],“and”:[12,40,80,91107114169198],“生物”:[13],“过程”:[14],“氨基“:[16,42,55,72112],”酸“:[17,56,73],”网络“:[18,76155],”(AAN)“:[19],”有“:[20],”成为“:[21],”一“:[22],”新兴“:[23],”范式“:[24],”研究“:[26],”FRs“:[27118148],”期间“:[28],”the“:[29,36,45,48,51,7011117120],”过去“:[30],”十年。“:[31],”当前“:[32],”AAN“:[33,46,67],”模型“:[34],”忽略“:[35],”异质性“:[37],”节点“:[39100],”处理“:[41],”酸“:[43113],”in“:[44],”作为“:[47],”相同。“:[49],”然而,“:[50],”属性“:[52109],”每个“:[54131],”节点“:[57],”是“:[58144],”基本“:[60],”重要性。“:[61],“我们”:[62,94123],“这里”:[63],“提议”:[64178],“a”:[65],“节点加权”:[66,71],“战略”:[68179],“术语”:[69],“联系人”:[74],“能量”:[75],“(NACEN)”:[77],“to”:[78129184],“特征化”:[79],“预测”:[81],“三”:[82],“类型”:[83],“FRs”:[85],“即”:[86],“热点”:[87],“斑点”:[88],“催化”:[89],“残留”:[90],“变构“:[92175],”残基。“:[93],“第一个”:[95],“构造的”:[96],“NACEN”:[97],“with”:[98119141153],“their”:[99],“weighted”:[101],“based”:[102],“on”:[103],“structural”,“:[104],“sequence”,“:[105],“physical,”:[106],“dynamical”:[108],“thern”:[115],“characterized”:[116140],“NACEN”:[121142162196],“parameters”。“:[122],“finally”:[124],“build”:[125],“machine”:[126],“learning”:[127],“predictors”:[128],“identified”:%130],“type”:[132],“FR.”:[134],“results”:%136],“discoved”:/137],“that”:[138],“parameters”::143],“more”:[145],“differentiable”:[146],“between”:[147],“non-FRs”:/150],“to”:[151],“那些”:[152],“未加权”:[154],“一。“:[156],”有“:[157],”少数“:[158],”特征“:[159],”分类“:[161],”产量“:[163],”可比“:[164],”性能“:[165],”FR“:[167],”标识“:[168],”提供“:[170],”残留“:[171187],”等级“:[172],”预测“:[173],”监管。“:[176],”can“:[180],”be“:[181],”easyly“:[182],”implemented“:[183],”other“:[185],”identification“。“:[188],”安“:[189],”R“:[190],”包“:[191],”也“:[193],”提供“:[194],”构造“:[197],”分析“:[199],”在“:[200],”网址:http://sysbio.suda.edu.cn/NACEN/index.html":[201],".“:[202]},”cited_by_api_url“:”https://api.openalex.org/works?filter=cites:W2887519731“,”counts_by_year“:[{”年“:2024,”cited_by_count“:3},{”年份“:2023,”ciped_by_cunt“:6},”{“年份”:2022,“cited_by_count”:6},{“年”:2021,”cited_by_count 48“,”创建日期“:”2018-08-22“}