{“id”:“https://openalex.org/W3026590542“,”doi“:”https://doi.org/10.1016/j.compbiochem.2020.107288“,”title“:“涉及非小细胞肺癌对吉非替尼获得性耐药的长非编码RNA的全基因组鉴定和特征描述”,“display_name”:“涉及非小细胞肺癌获得性耐药对吉非替尼的长非编码RNA的全基因鉴定和特征化”,“publication_year”:2020,”publication_date“:”2020-08-01“,”ids“:{”openalex“:”https://openalex.org/W3026590542“,”doi“:”https://doi.org/10.1016/j.compbiochem.2020.107288“,”mag“:”3026590542“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/32521497“},”language“:”en“,”primary_location“:{”is_oa“:false,”landing_page_url“:”https://doi.org/10.1016/j.compbiochem.2020.107288“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S104924063“,”display_name“:”计算生物学和化学“,”issn_l“:”1476-9271“,”isn“:[”1476-92“,”1476-9 28X“],”is_oa“:false,”is_ in_doaj“:false,”is_core“:true,”host_organization“:”https://openalex.org/P4310320990“,”“host_organization_name”:“Elsevier BV”,“host_organization_lineage”:[“https://openalex.org/P4310320990“],”host_organization_lineage_names“:[”Elsevier BV“],“type”:“journal”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false},”type“:”article“,”type_crossref“:“jornal-article”,“indexed_in”:[”crossref“,”pubmed“],‘open_access”:{“is_oa”:false,“oa_status”:“closed”,“oa_url”:空,“any_repository_has_fulltext”:假},“authorships“:[{”author_position“:”first“,”author“:{”id“:”https://openalex.org/A5091656435“,”display_name“:”晶晶石“,”兽人“:”https://orcid.org/0000-0002-2741-9915},“机构”:[{“id”:https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”晶晶石“,”raw _ afiliation_strings“:[“重庆医科大学生命科学研究所,中国重庆400016”],”affiliations“:[{”raw_ afiliation _string“:”重庆医科大生命科学研究院,中国重庆市400016https://openalex.org/I87780372“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5087906150“,”display_name“:”黄玉堂“,”orcid“:null},”机构“:[{”id“:”https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”Yutang Huang“,”raw _ afiliation_strings“:[“重庆医科大学生命科学研究所,中国重庆400016”],”affiliations“:[{”raw_ afiliation _string“:”重庆医科大生命科学研究院,中国重庆4000 16”,“institution_ids”:[“”https://openalex.org/I87780372“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5043606025“,”display_name“:”Chunjie Wen“,”orcid“:null},”institutions“:[{”id“:”https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]}],”countries“:[”CN“],”is_corresponding“:false,”raw_author_name“:”Chunjie Wen“,”raw _affiliation_strings“:【”重庆医科大学生命科学研究所,中国重庆400016“】,”affiliations“:[{”raw _affiliation_string“:”重庆医科院,中国重庆市400016“,”institution_ids“:[“”https://openalex.org/I87780372“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5031325476“,”display_name“:”帅和“,”兽人“:”https://orcid.org/0000-0002-2533-1020},“机构”:[{“id”:https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”帅和“,”raw _ afiliation_strings“:[“重庆医科大学生命科学研究所,中国重庆400016”],”affiliations“:[{”raw _affiliation_strong“:”重庆医科大生命科学研究院,中国重庆4000 16”,“institution_ids”:[“https://openalex.org/I87780372“]}]},{”author_position“:”middle“,”author“:{”id“:”https://openalex.org/A5035703876“,”display_name“:”Long\u2010Fei Wu“,”orcid“:”https://orcid.org/0000-0002-6687-2552},“机构”:[{“id”:https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]}],”国家“:[”CN“],”is_corresponding“:true,”raw_author_name“:”吴兰香“,”raw _ afiliation_strings“:[“重庆医科大学生命科学研究所,中国重庆400016”],”affiliations“:[{”raw_ afiliation _string“:”重庆医科大生命科学研究院,中国重庆市400016https://openalex.org/I87780372“]}]},{”author_position“:”last“,”author“:{”id“:”https://openalex.org/A5005160394“,”display_name“:”Hong\u2010Hao Zhou“,”orcid“:”https://orcid.org/0009-0009-4994-2318},“机构”:[{“id”:https://openalex.org/I139660479“,”display_name“:”中南大学“,”ror“:”https://ror.org/00f1zfq44“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I139660479“]},{”id“:”https://openalex.org/I87780372“,”display_name“:”重庆医科大学“,”ror“:”https://ror.org/017z00e58“,”country_code“:”CN“,”type“:“教育”,”世系“:[”https://openalex.org/I87780372“]},{”id“:”https://openalex.org/I4210145119“,”display_name“:”药物遗传学(中国)“,”ror“:”https://ror.org/03pcp9q42“,”country_code“:”CN“,”type“:“company”,”lineage“:[”https://openalex.org/I4210145119“]}],”国家“:[”CN“],”is_corresponding“:false,”raw_author_name“:”周鸿浩“,”raw _ afiliation_strings“:[“重庆医科大学生命科学研究所,重庆400016”,“中南大学临床药理学研究所药理学研究院,中国长沙410078”],”隶属关系“:[{”raw_affiliation_string“:”中南大学临床药理学研究所药物遗传学研究所,长沙410078,中国“institution_ids”:[“https://openalex.org/I139660479","https://openalex.org/I4210145119“]},{”raw_affiliation_string“:”重庆医科大学生命科学研究所,中国重庆400016“,”institution_ids“:[”https://openalex.org/I87780372“]}]}],”countries_disticont_count“:1,”institutions_disticent_count”:3,”corresponding_author_ids“:[”https://openalex.org/A5035703876“],”对应的机构ID“:[”https://openalex.org/I87780372“],”apc_list“:{”value“:2960,”currency“:”USD“,”value_USD“:29六十,”provenance“:”doaj“},”apc _pay“:null,”fwci“:0.441,”has_fulltext“:false,”cited_by_count“:5,”cited_by_percentile_year“:{”min“:82,”max“:84},“biblio”:{“volume”:“87”,”issue“:nul,”first_page“:”107288“,”last_page“:“107288”},“is_retracted”:false,“is_paratext”:false,“primary_topic”:{“id”:“https://openalex.org/T10515“,”“display_name”:“长非编码RNA在癌症和发展中的作用”,“score”:0.9998,“subfield”:{“id”:“https://openalex.org/subfields/1306“,”“display_name”“:”癌症研究“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},”主题“:[{”id“:”https://openalex.org/T10515“,”“display_name”:“长非编码RNA在癌症和发展中的作用”,“score”:0.9998,“subfield”:{“id”:“https://openalex.org/subfields/1306“,”“display_name”“:”癌症研究“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T10604“,”“display_name”:“RNA加工和功能的调节”,“score”:0.9471,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T10952“,”“display_name”:“生长和疾病中的mTOR信号”,“score”:0.9461,“subfield”:{“id”:“https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}}],”keywords“:[{”id“:”https://openalex.org/keywords/long非编码-rnas“,”display_name“:”长非编码RNA“,”score“:0.551118}],”concepts“:[{”id“:”https://openalex.org/C2780580887,“wikidata”:https://www.wikidata.org/wiki/Q417824“,”display_name“:”Gefitinib“,”level“:4,”score“:0.91848505},{”id“:”https://openalex.org/C86803240,“wikidata”:https://www.wikidata.org/wiki/Q420“,”display_name“:”生物学“,”等级“:0,”分数“:0.6565155},{”id“:”https://openalex.org/C145059251,“wikidata”:https://www.wikidata.org/wiki/Q310899“,”display_name“:”microRNA“,”level“:3,”score“:0.48359197},{”id“:”https://openalex.org/C104317684,“wikidata”:https://www.wikidata.org/wiki/Q7187“,”display_name“:”Gene“,”level“:2,”score“:0.4755787},{”id“:”https://openalex.org/C2776256026,“wikidata”:https://www.wikidata.org/wiki/Q47912“,”display_name“:”肺癌“,”level“:2,”score“:0.45501438},{”id“:”https://openalex.org/C502942594,“wikidata”:https://www.wikidata.org/wiki/Q3421914“,”display_name“:”癌症研究“,”level“:1,”score“:0.44984293},{”id“:”https://openalex.org/C62203573,“wikidata”:https://www.wikidata.org/wiki/Q15087973“,”display_name“:”长非编码RNA“,”level“:4,”score“:0.44418496},{”id“:”https://openalex.org/C105580179,“wikidata”:https://www.wikidata.org/wiki/Q188928“,”display_name“:”Messenger RNA“,”level“:3,”score“:0.431038},{”id“:”https://openalex.org/C70721500,“wikidata”:https://www.wikidata.org/wiki/Q177005“,”display_name“:”计算生物学“,”level“:1,”score“:0.42494884},{”id“:”https://openalex.org/C67705224,“wikidata”:https://www.wikidata.org/wiki/Q11053“,”display_name“:”RNA“,”level“:3,”score“:0.39157405},{”id“:”https://openalex.org/C54355233,“wikidata”:https://www.wikidata.org/wiki/Q7162“,”display_name“:”Genetics“,”level“:1,”score“:0.36278355},{”id“:”https://openalex.org/C121608353,“wikidata”:https://www.wikidata.org/wiki/Q12078“,”display_name“:”Cancer“,”level“:2,”score“:0.3462332},{”id“:”https://openalex.org/C2779438470网址,“wikidata”:https://www.wikidata.org/wiki/Q424401“,”display_name“:”表皮生长因子受体“,”level“:3,”score“:0.26946223},{”id“:”https://openalex.org/C71924100,“wikidata”:https://www.wikidata.org/wiki/Q11190“,”display_name“:”Medicine“,”level“:0,”score“:0.14651284},{”id“:”https://openalex.org/C143998085,“wikidata”:https://www.wikidata.org/wiki/Q162555“,”display_name“:”肿瘤学“,”level“:1,”score“:0.11522192}],”mesh“:[],”locations_count“:2,”location“:[{”is_oa“:false,”landing_page_url“:”https://doi.org/10.1016/j.compbiochem.2020.107288“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S104924063“,”display_name“:”计算生物学和化学“,”issn_l“:”1476-9271“,”isn“:[”1476-92“,”1476-9 28X“],”is_oa“:false,”is_ in_doaj“:false,”is_core“:true,”host_organization“:”https://openalex.org/P4310320990“,”“host_organization_name”:“Elsevier BV”,“host_organization_lineage”:[“https://openalex.org/P4310320990“],”host_organization_lineage_names“:[”Elsevier BV“],“type”:“journal”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false},{“is_oa”:false,“landing_page_url”:“https://pubmed.ncbi.nlm.nih.gov/32521497“,”pdf_url“:空,”源“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_ in_doaj“:false,”is_core“:false,”host_organization“:”https://openalex.org/I1299303238“,”“host_organization_name”:“美国国立卫生研究院”,“host_ordanization_lineage”:[“https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false}],“best_oa_location”:nul,“sustainable_development_goals”:[{“display_name”:“Good Health and welly”,“id”:“https://metadata.un.org/sdg/3“,”score“:0.8}],”grants“:[{”funder“:”https://openalex.org/F4320321001“,”“funder_display_name”:“国家自然科学基金”,“award_id”:“81603201”},{“funder”:“https://openalex.org/F4320321001“,”“funder_display_name”:“中国国家自然科学基金”,“award_id”:“81473284”}],“数据集”:[],“版本”:[],“referenced_works_count”:67,“referrenced_works”:[”https://openalex.org/W1670266242","https://openalex.org/W1925486158","https://openalex.org/W1965850768","https://openalex.org/W1988827171","https://openalex.org/W1989734503","https://openalex.org/W1996336635","https://openalex.org/W1998422171","https://openalex.org/W2005665711","https://openalex.org/W2007506240","https://openalex.org/W2008833309","https://openalex.org/W2053948868","https://openalex.org/W2057243176","https://openalex.org/W2061548680","https://openalex.org/W2075320162","https://openalex.org/W2087356589","https://openalex.org/W2122683221","https://openalex.org/W2123500593","https://openalex.org/W2147153508","https://openalex.org/W2147526198","https://openalex.org/W2155142785","https://openalex.org/W2163591924","https://openalex.org/W2171139285","https://openalex.org/W2339880891","https://openalex.org/W2341829316","https://openalex.org/W2470275708","https://openalex.org/W2508318399","https://openalex.org/W2561216063","https://openalex.org/W2601478161","https://openalex.org/W2607129810","https://openalex.org/W2735687500","https://openalex.org/W2767529657","https://openalex.org/W2769028639","https://openalex.org/W2773532330","https://openalex.org/W2791031844","https://openalex.org/W2793215860","https://openalex.org/W2804937140","https://openalex.org/W2807892422","https://openalex.org/W2807924383","https://openalex.org/W2809798146","https://openalex.org/W2810931141","https://openalex.org/W2883138166","https://openalex.org/W2883909272","https://openalex.org/W2883978878","https://openalex.org/W2889254343","https://openalex.org/W2895254819","https://openalex.org/W2897805491","https://openalex.org/W2897931324","https://openalex.org/W2904714967","https://openalex.org/W2906980458","https://openalex.org/W2915601187","https://openalex.org/W2934622391","https://openalex.org/W2941305753","https://openalex.org/W2943971555","https://openalex.org/W2945546354","https://openalex.org/W2946150866","https://openalex.org/W2950595506","https://openalex.org/W2957635805","https://openalex.org/W2963819833","https://openalex.org/W2969282649","https://openalex.org/W2969551456","https://openalex.org/W2969758464","https://openalex.org/W2985368231","https://openalex.org/W2998332147","https://openalex.org/W3013593965","https://openalex.org/W3014692283","https://openalex.org/W3024634060","https://openalex.org/W950232622“],”related_works“:[”https://openalex.org/W93672847","https://openalex.org/W4302360171","https://openalex.org/W3211998852","https://openalex.org/W2669545409","https://openalex.org/W2187035959","https://openalex.org/W2080867124","https://openalex.org/W2080648017","https://openalex.org/W2045486039","https://openalex.org/W2011516413","https://openalex.org/W1969883932“],”ngrams_url“:”https://api.openalex.org/works/W3026590542/ngrams“,”“abstract_inverted_index”:{“获得性”:[0],“抵抗力”:[1,45163],“是”:[2,30],“a”:[3,52],“主要”:[4],“障碍物”:[5],“to”:[6,46,62],“the”:[7,20,88138],“治疗性”:[8180],“疗效”:[9],“of”:[10,22,74,91104],“吉非替尼”:[11,47162],“in”:[12,7,48,87100137143160 164],“非小细胞”:[13],“肺”:[14],“癌症”:[15],“(非小细胞肺癌)。”:[16],“当前“:[17],”知识“:[18],”关于“:[19],”角色“:[21],”长“:[23],”非编码“:[24],”RNAs“:[25],”(lncRNAs)“:[26],”此“:[28,33],”现象“:[29],“不足”。“:[31],”In“:[32],”study“:[34],”we“:35],”searched“:[36],”RNA“:[37],”测序“:[38],”data“:[3]9],”for“:[40182],”lncRNAs“:[41,78,93122],”associated“:【42】,”with“:[C3],”acquired“:44161],”NSCLC“:[49],”and“:[50,57,68,79,94106123145148170172179],”构建“:[51],”功能“:[53],”lncRNA-mRNA“:[54],”共表达“:[55112],”网络”:[56,61113],“蛋白质”:[58],“相互作用”:[59],“(PPI)”:[60],“分析”:[63],“他们的”:[64],“假定的”:【65】,“目标”:【66】,“基因”:【67】,“生物”:【69】,“功能”。“:[70],”The“:[71111125151],”expression“:[72,89169],”levels“:[73,90],”14“:[75],”outstanding“:[76],”disregulated“:77132],”mRNA“:[80168],”were“:[81134],”verified“:[82],”using“:[83],”real-time“:+84],”PCR。“:[85],”更改“:[86],”39“:[92],”121“:[95],”mRNA“:[96133],”显示“:[97],”通用“:[98119],”模式“:[99],”我们的“:[101],”两个“:[102],”对“:[103],”吉非替尼敏感“:[105],”耐吉非替尼布“:[107183],”NSCLC“:[108165],”细胞“:[109],”行。“:[110],”包括“:[114],”1235“:[115],”连接“:[116],”中间“:[117],”这些“:[118],”差异“:[120],”表达“:[121],”mRNAs。“:[124],”显著“:[126],”丰富“:[127],”信号“:[128140],”通路“:[129],”基于“:[130],”关于“:[131],”主要“:[135],”涉及“:[136],”河马“:[139],”途径;“:[141],”蛋白多糖“:[142],”癌症;“:[144],”缬氨酸“,:[146],”亮氨酸“,“:[147],”异亮氨酸“:[149],”生物合成。“:[150],”results“:[152],”show“:[153],”that“:[154],”LncRNAs“:[155],”play“:[156],”an“:[157],”important“:%158],”part“:[159],”by“:[166],”regulation“:[167],”function“:[171],”may“:%173],”representation“:[174],”potential“:[175],”new“:+176],”molecular“:[177],”biomarkers“:%178],“目标”:[181],“NSCLC。“:[184]},”cited_by_api_url“:”https://api.openalex.org/works?filter=引用:W3026590542“,”counts_by_year“:[{“年份”:2023,”cited_by_count“:3},{“年度”:2022,”ciped_by_cunt“:1},”{“年”:2020,“cited_by_count”:1}],”updated_date“:”2024-06-28T04:17:19.312627“,”created_dates“:”2020年5月29日“}