{“id”:“https://openalex.org/W2912295484“,”doi“:”https://doi.org/10.1007/s10822-019-00189-w“,”title“:”AZT作为靶向A/PR/8/34/H1N1 RNA依赖性RNA聚合酶催化位点的抗流感核苷酸三磷酸“,”display_name“:”AZT作为靶向A/PR/8/34/H1N1 RNA依赖性RNA聚合酶催化位点的抗流感核苷酸三磷酸“,”publication_year“:2019,”publication_date“:”2019-02-09“,”ids“:{”openalex“:”https://openalex.org/W2912295484“,”doi“:”https://doi.org/10.1007/s10822-019-00189-w“,”mag“:”2912295484“,”pmid“:”https://pubmed.ncbi.nlm.nih.gov/30739239“},”language“:”en“,”primary_location“:{”is_oa“:true,”landing_page_url“:”https://doi.org/10.1007/s10822-019-00189-w,“pdf_url”:https://link.springer.com/content/pdf/10.1007/s10822-019-00189-w.pdf,“源”:{“id”:https://openalex.org/S64621741“,”display_name“:”计算机辅助分子设计杂志“,”issn_l“:”0920-654X“,”isn“:[”0920-6504X“、”1573-4951“],”is_oa“:false,”is_in_doaj“:false,”host_organization“:”https://openalex.org/P4310318900“,”“host_organization_name”:“Springer Science+Business Media”,“host_organization_lineage”:[“https://openalex.org/P4310319965","https://openalex.org/P4310318900“],”host_organization_lineage_names“:[”Springer Nature“,”Springer-Science+Business Media“],“type”:“journal”},“license”:null,“licence_id”:nul,“version”:“publishedVersion”,“is_accepted”:true,“is_published”:true},”type“:“article”,“type_crossref”:”journal-article“,”indexed_in“:[“crossref”,“publimed”],“open_access”:{“is_oa”:true,“oa_stat”美国“:”铜牌“,”oaurl“:”https://link.springer.com/content/pdf/10.1007/s10822-019-00189-w.pdf“,”any_repository_has_fulltext“:false},”authorships“:[{”author_position“:”第一“,”作者“:{”id“:”https://openalex.org/A5020982051“,”display_name“:”Nataraj Sekhar Pagadala“,”orcid“:”https://orcid.org/0000-0002-9759-0590“},”机构“:[{”id“:”https://openalex.org/I154425047“,”display_name“:”阿尔伯塔大学“,”ror“:”https://ror.org/0160cpw27“,”country_code“:”CA“,”type“:“教育”,”世系“:[”https://openalex.org/I154425047“]}],”国家“:[”CA“],”is_corresponding“:true,”raw_author_name“:”Nataraj Sekhar Pagadala“,”raw _ afiliation_strings“:[“加拿大埃德蒙顿阿尔伯塔大学医学微生物学与免疫学系”],”affiliations“:[{”raw _affiliation_strong“:”加拿大埃德蒙敦阿尔伯塔学院医学微生物学和免疫学系“,”机构ID“:[”https://openalex.org/I154425047“]}]}],”countries_disticont_count“:1,”institutions_disticent_count”:1,“corresponding_author_ids”:[“https://openalex.org/A5020982051“],”对应的机构ID“:[”https://openalex.org/I154425047“],”apc_list“:{”value“:2890,”currency“:”EUR“,”value_usd“:3690,”provenance“:”doaj“},”apc _payed“:null,”fwci“:0.831,”has_fulltext“:true,”fulltext_origin“:”pdf“,”cited_by_count“:6,”cited_by_percentile_year“:”{“min”:83,”max“:85},“biblio”:{“volume”:“33”,“issue”:“4”,“first_page”“:”387“,”last_page“:”404“},”is_retracted“:false,”is_paratext“:false,”主主题“:{”id“:”https://openalex.org/T10167“,”“display_name”:“流感病毒研究与流行病学”,“score”:0.9997,“subfield”:{“id”:“https://openalex.org/subfields/2713“,”display_name“:”流行病学“},”字段“:{”id“:”https://openalex.org/fields/27“,”display_name“:”Medicine“},”domain“:{”id“:”https://openalex.org/domains/4“,”display_name“:”Health Sciences“}},”topics“:[{”id“:”https://openalex.org/T10167“,”“display_name”:“流感病毒研究与流行病学”,“score”:0.9997,“subfield”:{“id”:“https://openalex.org/subfields/2713“,”display_name“:”流行病学“},”字段“:{”id“:”https://openalex.org/fields/27“,”display_name“:”Medicine“},”domain“:{”id“:”https://openalex.org/domains/4“,”“display_name”:“健康科学”}},{”id“:”https://openalex.org/T11668“,”display_name“:”天然病毒感染免疫“,”score“:0.9994,”subfield“:{”id“:”https://openalex.org/subfields/2403“,”display_name“:”免疫学“},”字段“:{”id“:”https://openalex.org/fields/24“,”display_name“:”免疫学和微生物学“},”域“:{”id“:”https://openalex.org/domains/1“,”display_name“:”生命科学“}},{”id“:”https://openalex.org/T10521“,”display_name“:”核糖体结构和翻译机制“,”score“:0.9992,”subfield“:{”id“:”https://openalex.org/subfields/1312“,”display_name“:”分子生物学“},”字段“:{”id“:”https://openalex.org/fields/13“,”“display_name”:“生物化学、遗传学和分子生物学”},“域”:{“id”:“https://openalex.org/domains/1“,”display_name“:”生命科学“}}],”关键词“:[{”id“:”https://openalex.org/keywords/抗病毒应答“,”display_name“:”抗病毒反应“,”score“:0.488898}],”concepts“:[{”id“:”https://openalex.org/C2779772310,“wikidata”:https://www.wikidata.org/wiki/Q16934561“,”display_name“:”Favipiravir“,”level“:5,”score“:0.77677464},{”id“:”https://openalex.org/C2776449523,“wikidata”:https://www.wikidata.org/wiki/Q272631“,”display_name“:”RNA聚合酶“,”level“:4,”score“:0.6923548},{”id“:”https://openalex.org/C82381507,“wikidata”:https://www.wikidata.org/wiki/Q416878“,”display_name“:”聚合酶“,”level“:3,”score“:0.5669497},{”id“:”https://openalex.org/C41258723,“wikidata”:https://www.wikidata.org/wiki/Q2919111“,”“display_name”“:”RNA-dependent RNA polymerase“,”level“:4,”score“:0.564728},{”id“:”https://openalex.org/C512185932,“wikidata”:https://www.wikidata.org/wiki/Q28745“,”display_name“:”核苷酸“,”level“:3,”score“:0.5432431},{”id“:”https://openalex.org/C67705224,“wikidata”:https://www.wikidata.org/wiki/Q11053“,”display_name“:”RNA“,”level“:3,”score“:0.5002117},{”id“:”https://openalex.org/C27775466802,“wikidata”:https://www.wikidata.org/wiki/Q834390“,”display_name“:”流感A病毒“,”level“:3,”score“:0.49058595},{”id“:”https://openalex.org/C159047783,“wikidata”:https://www.wikidata.org/wiki/Q7215“,”display_name“:”病毒学“,”level“:1,”score“:0.49023443},{”id“:”https://openalex.org/C86803240,“wikidata”:https://www.wikidata.org/wiki/Q420“,”display_name“:”生物学“,”等级“:0,”分数“:0.440493},{”id“:”https://openalex.org/C185592680,“wikidata”:https://www.wikidata.org/wiki/Q2329“,”display_name“:”Chemistry“,”level“:0,”score“:0.44021496},{”id“:”https://openalex.org/C179926584,“wikidata”:https://www.wikidata.org/wiki/Q207714“,”display_name“:”转录(语言学)“,”level“:2,”score“:0.4318825},{”id“:”https://openalex.org/C140704245,“wikidata”:https://www.wikidata.org/wiki/Q3933202“,”display_name“:”病毒复制“,”level“:3,”score“:0.4190818},{”id“:”https://openalex.org/C153911025,“wikidata”:https://www.wikidata.org/wiki/Q7202“,”display_name“:”分子生物学“,”level“:1,”score“:0.35443047},{”id“:”https://openalex.org/C181199279,“wikidata”:https://www.wikidata.org/wiki/Q8047“,”display_name“:”酶“,”level“:2,”score“:0.35206497},{”id“:”https://openalex.org/C55493867,“wikidata”:https://www.wikidata.org/wiki/Q7094“,”display_name“:”生物化学“,”level“:1,”score“:0.29962507},{”id“:”https://openalex.org/C2522874641,“wikidata”:https://www.wikidata.org/wiki/Q808“,”display_name“:”Virus“,”level“:2,”score“:0.2616278},{”id“:”https://openalex.org/C104317684,“wikidata”:https://www.wikidata.org/wiki/Q7187“,”display_name“:”Gene“,”level“:2,”score“:0.2500026},{”id“:”https://openalex.org/C71924100,“wikidata”:https://www.wikidata.org/wiki/Q11190“,”display_name“:”Medicine“,”level“:0,”score“:0.073234946},{”id“:”https://openalex.org/C41895202,“wikidata”:https://www.wikidata.org/wiki/Q8162“,”display_name“:”语言学“,”level“:1,”score“:0.0},{”id“:”https://openalex.org/C138885662,“wikidata”:https://www.wikidata.org/wiki/Q5891“,”display_name“:”哲学“,”等级“:0,”分数“:0.0},{”id“:”https://openalex.org/C2779134260,“wikidata”:https://www.wikidata.org/wiki/Q12136“,”display_name“:”Disease“,”level“:2,”score“:0.0},{”id“:”https://openalex.org/C142724271,“wikidata”:https://www.wikidata.org/wiki/Q7208“,”display_name“:”病理“,”level“:1,”score“:0.0},{”id“:”https://openalex.org/C3008058167,“wikidata”:https://www.wikidata.org/wiki/Q84263196“,”display_name“:”2019年冠状病毒病(COVID-19)“,”level“:4,”score“:0.0},{”id“:”https://openalex.org/C52420448,“wikidata”:https://www.wikidata.org/wiki/Q788926“,”display_name“:”传染病(医学专科)“,”level“:3,”score“:0.0}],”mesh“:[{”descriptor_ui“:”D000998“,”描述符名称“:”抗病毒药物“,”qualifier_ui”:“Q000494”,“qualifier _name”:“药理学”,“is_major_topic”:true},{”描述符ui“:”D020134“,”descriptor _name“:”催化域“,”限定符_ui药物效应“,”is_major_topic“:true},{”descriptor_ui“:”D053118“,”descriptor _name“:”流感A病毒,H1N1亚型“,”qualifier _ui”:“Q000201”,“qualifier_name”:“酶学”,“is_major_topic”:true},}“descriptor_ ui”:“D012324”,“descriptor _ name”:“RNA-依赖RNA聚合酶”,“qualifier _ ui“”:”Q000037“,”限定符_name“”:“拮抗剂和抑制剂”,“is_major_topic“:true},{“描述符_ui”:“D015215”,“描述符名称”:“齐多夫定”,“限定符_ui“:”Q000494“,”限定符名称“:”药理学“,”is_mayor_topical“:true},”描述符名称“:“D000998:“催化域“,”限定符_ui“:”“,”qualifier_name“:null,”is_major_topic“:false},{”descriptor_ui”:“D006801”,”描述符名称“:“人类”,“限定符_ui”:“”,“qualifier _name”:null,“is_mayor_topic:false{”描述符名称:“D053118”,“描述符名称”:“甲型流感病毒,H1N1亚型”,“qualifier_ui(限定符):“”、“限定符名称”:null、“is_mashor_topc”:false},{“descriptor_ui“:”D053118“,”descriptor_name“:”流感A病毒,H1N1亚型“,”限定符_ui”:“Q000187”,“限定符_name”:“药物效应”,“is_major_topic”:false},{“descriptor_ ui”:“D007251”,“descriptor _name”:“流感,人类”,“qualifier_ui:”“,”qualifier-name“:null,”is_mayor_topical“:false},”{“描述符_ui流感,人类“,”限定符_ui“:”Q000188“,”qualifier_name“:”药物治疗“,”is_major_topic“:false},{“描述符_ui”:“D062105”,“描述符_name”:“分子对接模拟”,“限定符_ui”:“”,“qualifier _name”:null,“is_mayor_topical”:false},}“描述符_ ui”:“D012324”,“descriptor_name”:“RNA-依赖RNA聚合酶”,“qualifier _ui):“Q000737”,“qualifier _name“:”chemistry“,”is_major_topic“:false},{”descriptor_ui“:”D012324“,”descriptor _name“:”RNA-Dependent RNA Polymerase“,”qualifier_ui”:“Q000378”,“qualifier-name”:“新陈代谢”,“is_mayor_topical”:false{”描述符_ui:“D012324”,“descriptor_name”:“RNA-Deependent RNA Polumerase”,“qualifier _ui(限定符_ ui):”,“限定符_name”:null,“is_ major_topic”:false},“”descriptor_ui“:”D015215“,”descriptor_name“:”Zidovudine“,”qualifier_ui”:“”,“qualifier _name”:null,“is_major_topic”:false}],“locations_count”:2,“location”:[{“is_oa”:true,“landing_page_url”:“https://doi.org/10.1007/s10822-019-00189-w,“pdf_url”:https://link.springer.com/content/pdf/10.1007/s10822-019-00189-w.pdf,“源”:{“id”:https://openalex.org/S64621741“,”display_name“:”计算机辅助分子设计杂志“,”issn_l“:”0920-654X“,”isn“:[”0920-6504X“、”1573-4951“],”is_oa“:false,”is_in_doaj“:false,”host_organization“:”https://openalex.org/P4310318900“,”“host_organization_name”:“Springer Science+Business Media”,“host_organization_lineage”:[“https://openalex.org/P4310319965","https://openalex.org/P4310318900“],”host_organization_lineage_names“:[”Springer Nature“,”Springer-Science+Business Media“],“type”:“journal”},“license”:null,“licence_id”:nul,“version”:“publishedVersion”,“is_accepted”:true,“is_published”:true},{“is_oa”:false,“landing_page_url”:“https://pubmed.ncbi.nlm.nih.gov/30739239“,”pdf_url“:null,”source“:{”id“:”https://openalex.org/S4306525036“,”display_name“:”PubMed“,”issn_l“:null,”issn“:null,”is_oa“:false,”is_ in_doaj“:false,”host_organization“:”https://openalex.org/I1299303238“,”host_organization_name“:”美国国立卫生研究院“,”host_organization_lineage“:[”https://openalex.org/I1299303238“],”host_organization_lineage_names“:[”National Institutes of Health“],“type”:“repository”},“license”:null,“licence_id”:null,“version”:null,“is_accepted”:false,“is_published”:false}],“best_oa_location”:{“is_oa”:true,“landing_page_url”:“https://doi.org/10.1007/s10822-019-00189-w,“pdf_url”:https://link.springer.com/content/pdf/10.1007/s10822-019-00189-w.pdf,“源”:{“id”:https://openalex.org/S64621741“,”display_name“:”计算机辅助分子设计杂志“,”issn_l“:”0920-654X“,”isn“:[”0920-6504X“、”1573-4951“],”is_oa“:false,”is_in_doaj“:false,”host_organization“:”https://openalex.org/P4310318900“,”“host_organization_name”:“Springer Science+Business Media”,“host_organization_lineage”:[“https://openalex.org/P4310319965","https://openalex.org/P4310318900“],”host_organization_lineage_names“:[”Springer Nature“,”Springer Science+Business Media“],”type“:”journal“},”license“:null,”license_id“:null,”version“:”publishedVersion“,”is_accepted“:true,”is_published“:true},”sustainable_development_goals“:[{”display_name“:”良好的健康和幸福“,”id“:”https://metadata.un.org/sdg/3“,”score“:0.43}],”grants“:[],”datasets“:[],”versions“:[】,”referenced_works_count“:56,”referrenced_works“:]”https://openalex.org/W1605151536","https://openalex.org/W1877114061","https://openalex.org/W1964610657","https://openalex.org/W1967687956","https://openalex.org/W1969072442","https://openalex.org/W1971428926","https://openalex.org/W1975106131","https://openalex.org/W1979122114","https://openalex.org/W1985444904","https://openalex.org/W1990180184","https://openalex.org/W1991311742","https://openalex.org/W2014166392","https://openalex.org/W2015642465","https://openalex.org/W2021192460","https://openalex.org/W2023016206","https://openalex.org/W2027847351","https://openalex.org/W2031812793","https://openalex.org/W2038565315","https://openalex.org/W2048043122","https://openalex.org/W2050333027","https://openalex.org/W2054896136","https://openalex.org/W2055043387","https://openalex.org/W2056760934","https://openalex.org/W2065283382","https://openalex.org/W2074231493","https://openalex.org/W2075261488","https://openalex.org/W2076952202","https://openalex.org/W2081903059","https://openalex.org/W2086919653","https://openalex.org/W2087818806","https://openalex.org/W2091795018","https://openalex.org/W2097602730","https://openalex.org/W2102993309","https://openalex.org/W2105910325","https://openalex.org/W2105918329","https://openalex.org/W2106882534","https://openalex.org/W2112481771","https://openalex.org/W2113451459","https://openalex.org/W2113712276","https://openalex.org/W2117254509","https://openalex.org/W2122449830","https://openalex.org/W2131993780","https://openalex.org/W2138274210","https://openalex.org/W2139855364","https://openalex.org/W2144813419","https://openalex.org/W2157839983","https://openalex.org/W2161239029","https://openalex.org/W2166280456","https://openalex.org/W2319650457","https://openalex.org/W2320185978","https://openalex.org/W2332229321","https://openalex.org/W2580062838","https://openalex.org/W2581765011","https://openalex.org/W2762968650","https://openalex.org/W2892275685","https://openalex.org/W4299526440“],”related_works“:[”https://openalex.org/W4210961822","https://openalex.org/W3157609033","https://openalex.org/W3096742390","https://openalex.org/W2970236921","https://openalex.org/W2729553993","https://openalex.org/W2228678012","https://openalex.org/W2176417755","https://openalex.org/W1997573290","https://openalex.org/W1974233081","https://openalex.org/W1971212384“],”ngrams_url“:”https://api.openalex.org/works/W2912295484/ngrams“,”“abstract_inverted_index”:{“To”:[0],“develop”:[1],“power”:[2],“drugs”:[3],“that”:[4105],“inhibit”:[5],”“the”:[6,45,56,70,76,79109131165173195204],“activity”:[7],“of”:[8,18,41,55,62,78,86,93111117133139150172181197208],“流感”:[9175209],“virus”:[10],“RNA”:[11,13],“依赖性”:[12],“聚合酶”:[14],“(RdRp),”:[15],“a“:[16,38,83124136147],”set“:[17],”compounds“:[19,49177],”favipiravir“:[20],”T-705“:[21],”T1105“:[22],”and“:[23,32],”T-1106,“:[24],”ribavirin“:[25],”ribavirin“:[26],”triphosphate“:[27],“viraminine,”:[28],“2FdGTP”:[2912],“(2'-脱氧2'-氟鸟苷“:[30],”三磷酸“:[31],”AZT-TP“:[33,66106],”(3'-叠氮-3'-脱氧胸腺嘧啶-5'-三磷酸)“:[34],”分别“:[35],”对接“:[36],”与“:[37,59,82135146159],”同源“:[39],”模型“:[40],”IAV“:[42,57185],”RdRp“:[43,58],”来自“:[44],”A/PR/8/34/H1N1“:[46],”菌株。“:[47],”这些“:[48],”绑定“:[50],”到“:[51,69,75128203],”四个“:[52],”口袋“:[53],”A-D“:[54],”不同“:[6079],”机制“:[61],”作用。“:[63],”In“:[64],”addition,“:[65],”also“:/67],”binds“:[68127],”PB1“:[71205],”catalystal“:[72206],”site“:[73207],“near”:[74],”tip“:[77],”priming“:[80],”loop“:[81],”maximum“:[84137],”\u0394G“:[85138],”-“:[87140],”16.7“:[88],”Kcal/mol“:[89137]142],“展览”:[90200],“an”:[91,97],“IC50”:[92149],“1.12”:[94151],“\u00b5M”:[95],“在“:[96,98115157178188],“体外”:[99],“酶”:[100],“转录”:[101],“分析”中。“:[102],”This“:[103187],”shows“:[104],”mainly“:[107],”预防“:[108],”掺入“:[110],”传入“:[112],”核苷酸“:[113],”参与“:[114],”起始“:[116],”vRNA“:[111882],”复制。“:[119],”相反,“:[120],”使用“:[122],”作为“:[123],”积极“:[125],”控制“:[126],”口袋B“:[129],”在“:[130],”结束“:[132],”隧道II“:[134],”16.3“:[141],”抑制“:[143],”链“:[144],”终止“:[145],”类似“:[148],”\u00b5M。“:[152],”总体“,:[153],”我们的“:[154],”计算“:[155],”结果“:[156],”相关性“:[158],”实验“:[160],”研究“:[161],”给出“:[162190],”信息“:[163],”对于“:[164194],”第一“:[166],”时间“:[167],”关于“:[168],”结合“:[170],”模式“:[171],”已知“:[174],”抗病毒“:[176],”模型“:[180],“复制”:[183],“通过”:[184],“RdRp。“:[186],“turn”:[189],“new”:[191198],“structural”:[192],“insights”:[193],“development”:[196],“theraputics”:[199],“high”:[201],“specificification”:[202],“A”:[210],“viruses”。“:[211]},”cited_by_api_url“:”https://api.openalex.org/works?filter=cites:W2912295484“,”counts_by_year“:[{”年“:2023,”cited_by_count“:1},{”年份“:2022,”ciped_by_cunt“:1\n,{“年”:2021,”cited_bycount“:2},”{“年份”:2020,“cited_by_count”:2}],“updated_date”:“2024-06-24T14:50:02.439429”,“创建日期”:“2019-02-21”}